Dendrimer Synthesis Service
Dendrimers are a class of polymers with nanoscale structures that are mainly used in biomedical applications. As the world's leading provider of custom services, CD BioSciences not only provides you with various methods to synthesize dendrimers, but also to synthesize different dendrimers according to your needs, thus helping you to advance the downstream applications of dendrimers.
Introduction to Dendrimers
As an amazing chemical molecule, dendrimers are the fourth class of polymers that have made great strides since their inception. Dendrimers are mainly used in biomedical applications and are valuable in diagnostics and therapeutics due to their ability to improve drug solubility, absorption, bioavailability, and targeted drug distribution.
Dendrimer structures-from central structure to periphery, 0-4 generations, linear diametral growth. (Chis AA, et al., 2020)
- Origin of Dendrimers
The term " dendrimers " is a combination of two Greek words "dendron" and "meros", translated as tree and parts, thus explaining their branched structure. Flory first proposed the idea of dendrimers in 1941. The first paper on dendrimers was the synthesis of dendrimers by divergent synthesis, published by Vögtle and coworkers in 1978. The convergent method for dendrimers was proposed by Hawker and Frechet in 1990.
- Characteristics of Dendrimers
In contrast to conventional polymers, dendrimers are characterized by branched repeating units emerging from a focal point and possessing many exposed anionic, neutral, or cationic terminal functions on the surface, thus behaving as hydrophilic or hydrophobic compounds. They are nanoscale molecules that are radially symmetric, spherical, monodisperse and homogeneous. Due to their size, dendrimers are used in nanomedicine research.
- Applications of Dendrimers
In addition to their inherent antibacterial medicinal value, dendrimers can be used as drug and gene delivery system. When they are used as carriers, dendrimers offer many advantages over conventional surfactants. For example, high loading capacity due to numerous functional surface groups and internal cavity structure, improved bioavailability of drugs by covalent or non-covalent means, and high penetration of biological barriers and cell membranes. In addition, dendrimers can be applied in imaging techniques, improving the treatment of diseases such as cancer, cardiovascular diseases, inflammatory diseases, and viral and bacterial infections.
What We Provide
Using our powerful organic chemistry platform, CD BioSciences can provide our customers with customized synthesis services for a variety of dendrimers, helping them to develop effective strategies for efficient synthesis of dendrimers.
How We Can Help
As a rapidly growing, leading global provider of scientific research services and solutions, CD BioSciences is committed to providing our customers with a variety of methods to synthesize dendrimer macromolecules.
Dendrimers divergent synthesis focuses on the design of a key intermediate that starts with a core construct and uses two basic operations to gradually build the molecule outward.
Commonly used for the total synthesis of complex molecules in chemical synthesis, where different target molecules are synthesized separately and then combined to obtain dendrimers.
Click chemistry, one of the important high-yield reactions, has been rapidly applied to the synthesis of dendrimers since its inception, with the aim of producing environmentally friendly dendrimers.
Other Synthesis Methods
CD BioSciences offers you other synthetic methods for dendrimer in addition to divergent, convergent and click chemistry methods, which you can choose according to your needs.
CD BioSciences helps our customers meet the growing and evolving demand for dendrimer products. We guarantee that all deliverables undergo rigorous quality testing to ensure quality and reliability and are delivered on time. If you are interested in our services or have any additional questions, please feel free to contact us, we would be happy to hear from you and look forward to working with you.
Reference
- Chis AA.; et al. Applications and Limitations of Dendrimers in Biomedicine. Molecules. 2020, 25: 3982-4024.
For research use only. Not for clinical use.
