CBS Dendrimer Synthesis Service
Carbosilane dendrimers (CBSs) is a silicon-based dendrimer with a strong C-Si bond. As the world's leading provider of custom services, CD BioSciences has the advanced equipment and experienced scientists to offer you CBS dendrimer synthesis services.
Overview of CBS Dendrimers
A dendrimer is a hyperbranched macromolecule consisting of a central core surrounded by branches called "dendrons". Depending on the branch, the dendrimer can be 1st generation dendrimers (1 G), 2nd generation dendrimers (2 G), 3rd generation dendrimers (3 G), etc. The higher the number of generations of dendrimer, the higher the number of functional groups. The multivalent surface of dendrimers and the flexible microenvironment within the branches enable them to be widely used in biomedicine as carriers for delivery of various biomolecules. poly-amidoamine (PAMAM) is one of the most used dendrimers and was the first dendrimer to be synthesized.
Other known dendrimers include poly (propylene imine) dendrimers (PPI), carbosilane dendrimers (CBS) and sulfonimide-based dendrimers (SBD), of which CBS is a silicon-based dendrimer with a strong C-Si bond where the silicon atom is the branching point of each generation.
Synthesis of CBS Dendrimers
As the most important class of silyl dendrimers, CBS dendrimers were first synthesized by Fetters in 1978. The synthetic strategy was based on a sequential reaction of hydrosilylation of alkenyl groups and subsequent ω-alkenylations with Grignard reagents. The synthetic route is highly versatile and does not require drastic changes in reaction conditions, enabling the introduction of different hydrosilylation reagents, ω-alkenylation reagents, and core molecules such as SiCl4. In addition, click chemistry or other reactions can be used for the synthesis of CBS dendrimers.
Advantages of CBS Dendrimers
As a dendrimer, CBS dendrimers are often synthesized for use in siRNA and oligonucleotide delivery systems. In addition, second generation cationic CBS hold great promise in the field of gene therapy because they have low toxicity and can be retained and internalized as genetic material such as oligonucleotides or siRNAs. When used as a delivery system CBS dendrimer has the following advantages.
- Because of the strong C-Si bonds, CBS dendrimers have high kinetic and thermodynamic stability.
- CBS dendrimers can be easily functionalized.
- CBS dendrimers have a hydrophobic backbone while being water soluble when functionalized with polar groups to promote hydrophobic and hydrophilic interactions.
- CBS dendrimers have highly flexible and biocompatible.
General structure of carbosilane dendrimers. (Herma R, et al., 2019)
Our Services
CD BioSciences offers a wide range of chemical synthesis methods for the synthesis of CBS dendrimers and guarantee that all deliverables are subjected to rigorous quality testing and delivered on time to ensure quality and reliability.
What We Provide
Dendrimers divergent synthesis focuses on the design of a key intermediate that starts with a core construct and uses two basic operations to gradually build the molecule outward.
Commonly used for the total synthesis of complex molecules in chemical synthesis, where different target molecules are synthesized separately and then combined to obtain dendrimers.
Click chemistry, one of the important high-yield reactions, has been rapidly applied to the synthesis of dendrimers since its inception, with the aim of producing environmentally friendly dendrimers.
Other Synthesis Methods
CD BioSciences offers you other synthetic methods for dendrimer in addition to divergent, convergent and click chemistry methods, which you can choose according to your needs.
Service Process
As a rapidly growing, leading global provider of scientific research services and solutions, CD BioSciences is committed to helping our customers meet the growing and evolving demand for dendrimer products. We offer services for the synthesis of a variety of dendrimers such as PAMAM dendrimers, PPI dendrimers, CBS dendrimers, sulfonimide-based dendrimers, and phosphorus dendrimers. If you are interested in our services or have any other questions, please feel free to contact us, we would be happy to hear from you and look forward to working with you.
Reference
- Herma R, et al., Carbosilane dendrimers with phosphonium terminal groups are low toxic non-viral transfection vectors for siRNA cell delivery. Int J Pharm. 2019, 562: 51-65.
For research use only. Not for clinical use.
