Divergent Synthesis Strategy for Dendrimers

Divergent synthesis is a chemical synthesis strategy that can improve the efficiency of synthesis. Divergent synthesis of dendrimers is constructed from the core. CD BioSciences has the advanced equipment and experienced scientists to provide you with divergent synthesis of dendrimers.

Divergent Synthesis - An Efficient Chemical Synthesis Strategy

As a chemical synthesis strategy that can improve the efficiency of synthesis, divergent synthesis was first introduced by Boger in 1984 and is a landmark. Divergent synthesis, as the name implies, requires the conversion of identical intermediates (preferably advanced intermediates) into at least two members of the class, respectively. The focus of the divergent synthesis strategy is to design a key intermediate that can be further diversified into a set of molecules related to the target scaffold, i.e., the next generation compound is produced by further reactions with each compound in generation 1.

• A generates A1, A2, A3, A4, A5 in generation 1.
• A1 generates A11, A12, A13 in generation 2, and so on.

Thus, the most important challenge in divergent synthesis is the selection of a common intermediate that can be transformed into a target array of natural products and non-natural derivatives. Dispersion synthesis is often an alternative to convergent or linear synthesis and is widely used by medicinal chemists in the field of natural product synthesis and is a powerful tool in organic synthesis.

Divergent total synthesis. (Rodríguez-García I, et al., 2021)

Divergent Synthesis for Dendrimers

The divergent synthesis of dendrimers is constructed starting from the core, using two basic operations to gradually build the molecule outward, adding one generation to the structure of the dendrimer with each additional layer of branching units. The specific steps are represented by the first coupling of the monomers used to synthesize the dendrimer, followed by the deprotection or transformation of the monomer end groups to form a new reactive surface, and then coupling of a new monomer, etc. As the number of generations of dendrimers increases, the number of reactions must increase simultaneously, so this synthetic approach may seem simple, but requires very efficient reactions to avoid structural errors in the synthesized dendrimers.

Schematic representation of (a) Divergent synthesis and (b) Convergent methods of synthesis of dendrimers. (Sherje AP, et al., 2018)

The divergent synthesis of dendrimers involves two main problems.

• Slower Reaction Kinetics
  As the number of reaction sites increases rapidly during synthesis, the reaction kinetics of dendrimers slows down, making it difficult to produce higher generation products.

• The Target Products Are Difficult to Isolate
  During the synthesis of dendrimer macromolecules, the separation of the target products is difficult because the resulting by-products are highly like the desired product molecules.
  Despite the above major problems of divergent synthesis, the method still has an important role in the synthesis of dendrimers. Provided that the appropriate coupling method, activation steps and reagents, and reaction conditions are selected, the divergent synthesis is well suited for large-scale preparation of dendrimers, as the number of dendrimer samples essentially doubles with each generation.

Our Services

As a rapidly growing, leading global provider of scientific research services and solutions, CD BioSciences provides services for the divergent synthesis of dendrimer and guarantees that all deliverables are subjected to rigorous quality testing.

What We Provide

Service Process

CD BioSciences is committed to helping our customers meet the growing and evolving demand for dendrimer products. We ensure quality and reliability of results and on-time delivery. If you are interested in our services or have any additional questions, please feel free to contact us, we would be happy to hear from you and look forward to working with you.

References

1. Rodríguez-García I, López-Martínez JL. Divergent Strategy in Marine Tetracyclic Meroterpenoids Synthesis. Mar Drugs. 2021, 19:273-288.
2. Sherje AP.; et al. Dendrimers: A versatile nanocarrier for drug delivery and targeting. Int J Pharm. 2018, 548:707-720.