Peptide Dendrimer Synthesis Service
Peptide dendrimers synthesized by organic chemistry are promising biomaterials with many applications in medicine. CD BioSciences has the advanced equipment and experienced scientists to offer you peptide dendrimer synthesis services.
Overview of Peptide Dendrimers
The branched structure of peptide dendrimers has a peptide or non-peptide core, which improves the stability and enhances the peptide function compared to small linear peptides. Peptide dendrimers have cores, building blocks and branching units or surface functional groups that can also be covalently linked to other chemical or biological molecules. Depending on the position of amino acids in the dendrimer, peptide dendrimers can be classified into three categories. The first and second categories are covalent peptide dendrimers, prepared from natural or non-natural amino acids, which can be incorporated into the core, building blocks, or branching units of the dendrimer. Types I and II are the covalent peptide dendrimers, prepared from natural or un-natural amino acids, incorporated into the dendrimer core, building blocks, or branching units. Type III is non-covalent peptide dendrimers, in which amino acids or peptides residues complex non-covalently with a non-peptidic framework at surface.
Typical structure of a peptide dendrimer. (Tabatabaei Mirakabad FS, et al., 2019)
Applications of Peptide Dendrimers
Peptide dendrimers are one of the promising biomaterials that are used as therapeutic or targeting agents in various fields of medicine, mainly as active drug components and drug delivery carriers.
- Therapeutic Applications of Peptide Dendrimers
The biocompatibility and low toxicity of peptide dendrimers make them attractive materials for clinical applications. Peptide dendrimers not only have potent antibacterial activity and anticancer activity, but also act as antithrombotic agents. When used as antigen delivery agents, peptide dendrimers can deliver vaccines or serum diagnostic antigens associated with bacterial or viral infections. In addition, peptide dendrimer macromolecules can also be designed as specific protein agonists or antagonists. - Drug Delivery of Peptide Dendrimers
Due to their small and designable structure, dendrimers can be used as drug carriers in addition to their therapeutic role. Mainly gene delivery and chemotherapeutic drug delivery. Peptide dendrimers are one of the candidate molecules for non-viral carriers for delivery of nucleic acids because of their unique properties such as controllable three-dimensional molecular architecture (shape and size), low polydispersity, highly adjustable surface chemistry, biocompatibility, high cellular uptake, and endosomal scape. In addition, peptide dendrimers are of great interest for dermal and oral therapeutic drug applications.
Synthesis of Peptide Dendrimers
Dendrimers are hyper-branched structures with a central core and flexible surface functionality that can entrap, complex and/or conjugate with therapeutic agents, and they are attractive carriers for drugs. Currently, dendrimers can be synthesized by many chemical methods, as well as methods to improve their physicochemical characteristics and biocompatibility. Dendrimers prepared by polymerization of amino acids or small peptide units are called peptide dendrimers, in other words, peptide dendrimers are generally dendrimers with peptide bonds in their structure.
Our Services
CD BioSciences offers a wide range of chemical synthesis methods for the synthesis of peptide dendrimers and guarantee that all deliverables are subjected to rigorous quality testing and delivered on time to ensure quality and reliability.
What We Provide
Dendrimers divergent synthesis focuses on the design of a key intermediate that starts with a core construct and uses two basic operations to gradually build the molecule outward.
Commonly used for the total synthesis of complex molecules in chemical synthesis, where different target molecules are synthesized separately and then combined to obtain dendrimers.
Click chemistry, one of the important high-yield reactions, has been rapidly applied to the synthesis of dendrimers since its inception, with the aim of producing environmentally friendly dendrimers.
Other Synthesis Methods
CD BioSciences offers you other synthetic methods for dendrimer in addition to divergent, convergent and click chemistry methods, which you can choose according to your needs.
Service Process
As a rapidly growing, leading global provider of scientific research services and solutions, CD BioSciences is committed to helping our customers meet the growing and evolving demand for dendrimer products. We offer services for the synthesis of a variety of dendrimers such as PAMAM dendrimers, PPI dendrimers, CBS dendrimers, sulfonimide-based dendrimers, phosphorus dendrimers and peptide dendrimers. If you are interested in our services or have any other questions, please feel free to contact us, we would be happy to hear from you and look forward to working with you.
Reference
- Tabatabaei Mirakabad FS., et al. Peptide dendrimers as valuable biomaterials in medical sciences. Life Sci. 2019, 12:1-12.
For research use only. Not for clinical use.
