PPI Dendrimer Synthesis Service
Poly(propyleni-mine) (PPI) dendrimers are promising three-dimensional polymers for pharmaceutical and biomedical applications. As the world's leading provider of custom services, CD BioSciences has the advanced equipment and experienced scientists to offer you PPI dendrimer synthesis services.
Overview of PPI Dendrimers
There are many types of dendrimers, among which polyamido-amines (PAMAM), poly-L-lysine (PLL) and poly(propyleni-mine) (PPI) are currently commercialized and widely used in biomedicine. Among them, PPI dendrimers are promising three-dimensional polymers for pharmaceutical and biomedical applications, generally characterized by the presence of primary amine terminal groups and tertiary propylene amines inside the PPI structure. The main mechanism of action of PPI dendrimers is to increase the solubility of conjugated drugs through electrostatic interactions, and their main advantages include easy surface modification, allowing for high-substituted dendrimers, and drug delivery versatility and high functionality.
Applications of PPI Dendrimers
Dendrimers are highly branched, fully monodisperse macromolecules with a precisely controlled chemical structure. The term “dendrimers” is a combination of two Greek words "dendron" and "meros", which translate to tree and parts. The first paper on dendrites was published in 1978 by Vögtle and coworkers, who created dendritic structures by using divergent synthesis. The convergent synthesis method that followed was proposed by Hawker and Frechet in 1990. As a synthetic polymer, dendrimers emerge from a focal point with repeated branching units that expose many anionic, neutral, or cationic terminal functions on their surface, resulting in dendrimers that become hydrophobic or hydrophilic compounds.
- Medicinal Value
PPI dendrimers have their own medicinal value because of their antibacterial and cytotoxic properties. In addition, when dendrimers are used as drug carriers, they can solve problems such as poor solubility and stability of drugs and high toxicity.
- Drug Carriers
Compared with conventional surfactants, PPI dendrimers have many advantages when used as carriers, such as high drug loading capacity by numerous functional surface groups and internal cavities, and high bioavailability of drugs through covalent or non-covalent bonding.
- Gene Carriers
Unlike conventional polymers, PPI dendrimers are radially symmetric, spherical, monodisperse and homogeneous nanomolecular that can be used as carriers for gene transfection.
- Other Applications
PPI dendrimers can also be used for diagnostic imaging techniques and for the treatment of cancer, cardiovascular diseases, and inflammatory diseases, among others.
Synthesis of PPI Dendrimers
Current chemical synthesis methods used for PPI dendrimers include divergent synthesis, convergent synthesis, and click chemistry-based synthesis methods.
Synthesis of PPI dendrimers. (García-Gallego S, et al., 2017)
Our Services
CD BioSciences offers a wide range of chemical synthesis methods for the synthesis of PPI dendrimers and guarantee that all deliverables are subjected to rigorous quality testing and delivered on time to ensure quality and reliability.
What We Provide
Dendrimers divergent synthesis focuses on the design of a key intermediate that starts with a core construct and uses two basic operations to gradually build the molecule outward.
Commonly used for the total synthesis of complex molecules in chemical synthesis, where different target molecules are synthesized separately and then combined to obtain dendrimers.
Click chemistry, one of the important high-yield reactions, has been rapidly applied to the synthesis of dendrimers since its inception, with the aim of producing environmentally friendly dendrimers.
Other Synthesis Methods
CD BioSciences offers you other synthetic methods for dendrimer in addition to divergent, convergent and click chemistry methods, which you can choose according to your needs.
Service Process
As a rapidly growing, leading global provider of scientific research services and solutions, CD BioSciences is committed to helping our customers meet the growing and evolving demand for dendrimer products. We offer services for the synthesis of a variety of dendrimers such as PAMAM dendrimers, PPI dendrimers, CBS dendrimers, sulfonimide-based dend rimers, and phosphorus dendrimers. If you are interested in our services or have any other questions, please feel free to contact us, we would be happy to hear from you and look forward to working with you.
Reference
- García-Gallego S., et al. Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials. Molecules. 2017, 22:1581-1610.
For research use only. Not for clinical use.
