Sulfonimide-based Dendrimer Synthesis Service

Sulfonimide-based dendrimers (SBDs) can be used in organic synthesis as starting reagents for the polymerization and synthesis of high generation dendrimers. As the world's leading provider of custom services, CD BioSciences has the advanced equipment and experienced scientists to offer you sulfonimide-based dendrimer synthesis services.

Overview of Sulfonimide-based Dendrimers

The physicochemical properties of dendrimers, such as e.g., monodispersity, multivalency and globular shape, distinguish them from classical polymers and are used in a wide range of applications in chemistry, biology, medicine, biotechnology, as well as in the pharmaceutical and food industries. There are more than 50 families of dendrimers, some of which, such as PAMAM, have been intensively studied and are widely used in biomedicine, while others are just starting to attract the attention of researchers. As a promising dendrimer, sulfonimide-based dendrimers (SBDs), can be used in organic synthesis as starting reagents for the polymerization and synthesis of high generation dendrimers. Like other dendrimers, the chemical and physical properties of SBDs depend on the shell formed by functional groups, and different terminal groups confer different properties to SBDs.

Structure of Sulfonimide-based Dendrimers

In terms of size, dendrimers are organic nanoparticles (e.g., liposomes, carbon nanomaterials, and polymer micelles). As nanoparticles, they do not exceed 15 nm in size, and they exhibit unique size-dependent physical and chemical properties. The 5th generation SBD do not exceed 5 nm in size. SBDs are characterized by two sulfonyl groups (-SO2) bound to the nitrogen atom from one side and to carbon from the other side. Aromatic SBDs structures contain peripheral methyl and nitro groups that can be chemically converted to carboxylic acids and amines for further chemical or biological modifications.

Structure of dendrimers and SBD. (Bondareva JV, et al., 2020)

Synthesis of Sulfonimide-based Dendrimers

Since the first synthesis of dendrimers in 1978, dendrimers have received a lot of attention in organic, super and polymer chemistry. Like other dendrimers, SBDs are usually synthesized using both divergent and convergent approaches, but with the development of organic chemistry, more and more new techniques are being developed.

• Divergent Synthesis of Sulfonimide-based Dendrimers
  Divergent synthesis of dendrimers is constructed from the core, using two basic operations to gradually build the molecule outward, adding one generation to the structure of the dendritic polymer with each additional layer of branching units. Prof. Vögtle et al., obtained sulfonamide-substituted G2-G4 polypropylene amine (POPAM) dendrimers by N-monosulfonylation and N-bissulfonylation, achieving the first synthesis of SBDs. Subsequently, they reported another synthesis in 2004 - dendrimers with sulfonimide units at the branching point.

• Convergent Synthesis of Sulfonimide-based Dendrimers
  In contrast to divergent synthesis, convergent synthesis uses separate synthesis of different target molecules, which are then combined to obtain the product. SBDs, like the well-known commercial dendrimers (e.g., PAMAM and PPI), are usually synthesized using divergent synthesis. The disadvantage of divergent synthesis is that the product decreases significantly as the production of dendrimers increases and higher generations of products accumulate. Convergent synthesis is often used to simplify synthesis and purification and provides better yields of high-generation dendrimers.

• Click Chemistry of Sulfonimide-based Dendrimers
  In chemical synthesis, click chemistry is a class of biocompatible small-molecule reactions that allow rapid and reliable chemical synthesis of various molecules by connecting small modular units. Click chemistry has contributed greatly to the field of chemical synthesis, with applications in many fields such as drug development and biomedical materials and has become one of the most useful and attractive methods for chemical synthesis. Click chemistry, one of the important high-yield reactions, has been rapidly applied to dendrimer synthesis since its inception, with the aim of producing carbon-rich and environmentally friendly dendrimers.

Our Services

CD BioSciences offers a wide range of chemical synthesis methods for the synthesis of sulfonimide-based dendrimers and guarantee that all deliverables are subjected to rigorous quality testing and delivered on time to ensure quality and reliability.

What We Provide

Divergent Synthesis

Convergent Synthesis

Click Chemistry

Other Synthesis Methods

Service Process

As a rapidly growing, leading global provider of scientific research services and solutions, CD BioSciences is committed to helping our customers meet the growing and evolving demand for dendrimer products. We offer services for the synthesis of a variety of dendrimers such as PAMAM dendrimers, PPI dendrimers, CBS dendrimers, sulfonimide-based dendrimers, and phosphorus dendrimers. If you are interested in our services or have any other questions, please feel free to contact us, we would be happy to hear from you and look forward to working with you.

Reference

1. Bondareva JV., et al. Sulfonimide-Based Dendrimers: Progress in Synthesis, Characterization, and Potential Applications. Polymers (Basel). 2020, 12:2987-3014.