PAMAM Dendrimer Synthesis Service
Polyamido-amines (PAMAM) is the first dendrimer to be synthesized and commercialized and is the most well-studied and characterized class of dendrimers. As the world's leading provider of custom services, CD BioSciences has the advanced equipment and experienced scientists to offer you PAMAM synthesis services.
Overview of PAMAM Dendrimers
Poly(amidoamine), or PAMAM, is the first dendrimer to be synthesized and commercialized and is the most well-studied and characterized class of dendrimers consisting of repeating branched subunits of amide and amine functionality, which are three-dimensional molecules with repeating branched chains. The core of PAMAM consists of linear chain molecules containing primary amines, most commonly ethylenediamine (EDA, four core multiplicity), ammonia (three core multiplicity) or cystamine (four core multiplicity).
Like other dendritic polymers, PAMAM has an overall sphere-like shape and is typified by an internal molecular structure composed of tree-like branching, with each outward "layer" or generation containing exponentially more branching points. The branched structure of PAMAM allows for low polydispersity and a high level of structural control during synthesis and generates many surface sites relative to the overall molecular volume, thus distinguishing it from other dendritic or conventional polymers. In addition, it is possible that PAMAM exhibits greater biocompatibility due to the combination of surface amine and internal amide bonds.
Common cores and G0 PAMAM derivatives of each core. (Araújo RV, et al., 2018)
Structure of PAMAM Dendrimers
As a class of nanoscale compounds with well-defined monodisperse and homogeneous molecular structures, dendrimers are considered as the fourth and newest class of polymers. Moreover, dendrimers differ from classical oligomers/polymers due to their symmetry, high molecularity, and maximum terminal functional density. Dendrimers consist of three main components.
- The core, which serves as the "germinating seed" and is the anchor point for the growth of the dendrimers.
- The inner layers and internal branches that make up the generations.
- An outer layer, the terminal functionalized branch.
Dendrimer ends can be modified by small molecules (including ions, drugs, and biomolecules) that alter the physicochemical, reactive, kinetic, and biological properties of the dendrimer ground.
Dendrimers: general structure. (Araújo RV, et al., 2018)
Synthesis of PAMAM Dendrimers
There are generally many methods for the synthesis of dendrimers, of which convergent and divergent methods are the most common ones. In addition, many new methods have been developed, such as click chemistry, hypercores, branching monomers and double exponential, etc., which can also be used to synthesize dendrimers by a combined convergent-divergent approach.
Our Services
CD BioSciences offers a wide range of chemical synthesis methods for the synthesis of PAMAM and guarantee that all deliverables are subjected to rigorous quality testing and delivered on time to ensure quality and reliability.
What We Provide
Service Process
As a rapidly growing, leading global provider of scientific research services and solutions, CD BioSciences is committed to helping our customers meet the growing and evolving demand for dendrimer products. We offer services for the synthesis of a variety of dendrimers such as PAMAM dendrimers, PPI dendrimers, CBS dendrimers, sulfonimide-based dendrimers, and phosphorus dendrimers. If you are interested in our services or have any other questions, please feel free to contact us, we would be happy to hear from you and look forward to working with you.
Reference
- Araújo RV., et al. New Advances in General Biomedical Applications of PAMAM Dendrimers. Molecules. 2018, 23:2849-2876.
For research use only. Not for clinical use.
