In vivo delivery kits are used to transport molecules such as DNA, RNA, proteins and peptides into eukaryotic cells. In vivo delivery agents impart an overall positive charge to DNA, RNA, and certain negatively charged proteins by forming complexes, thereby helping to overcome barriers caused by the negative charge of target molecules and cell membranes. This interaction is necessary to trigger the cellular uptake of the complex and its subsequent release from the vesicle into the cytoplasm.
Figure 1. Engineered materials for In vivo delivery of genome-editing machinery. (Tong S, et al.; 2019)
CD BioSciences provides optimized In vivo delivery kit, through the precise design and modification of delivery carriers, as well as advanced technology platforms, can help you solve:
The challenges you might meet:
- There is no suitable method to deliver target molecules to specific tissues and organs in the body
- Target molecules do not readily cross cell membranes due to their size and surface chemistry
- Low payload for In vivo delivery systems
- Target molecules are diluted and degraded during In vivo delivery without protection
- Poor stability of target molecules In vivo
- Uncontrolled release of target molecules In vivo
- Etc…
Key Features
- POLYMER Transfection Kit
- Pancreas Transfection Kit
- Kidney Transfection Kit
- Brain Transfection Kit
- Liver Transfection Kit
- Lung Transfection Kit
- PEG-Liposome Transfection Kit
- LIPID Transfection Kit
- Nanoparticle Transfection Kit
Our Advantage:
- CD BioSciences can provide professional target molecules delivery system In vivo to achieve efficient delivery In vivo;
- Our delivery system can add modified ligands to achieve targeting;
- In vivo target molecules delivery system, low toxicity to the body, safe to use
- In vivo target molecules delivery system protects the functional protein from being diluted and degraded during In vivo delivery
- The delivery system can realize timing, fixed point, fixed speed and targeted release in the body, so that the experimental animals can have a long-lasting effect after a single injection
- The system load is high, which can meet the delivery needs of different doses
- Professional design and service team to provide you with reliable service and technical support, timely feedback technical reports
- Optimized material composition improves delivery efficiency and stability
- Fluorescent carrier facilitates tracking and imaging of target molecules
- Ready-to-use
Application candidates:
- Efficient delivery to the brain, heart, lung, liver, pancreas, kidney, and multiple tumor types via tail vein administration
- Functional testing in mice (BALB/c, Nude, NOD/SCID) and Sprague Dawley rats
- The complex is stable in serum for 16 hours. Suitable for co-injection of plasmid DNA, siRNA and other molecules
- Efficient delivery of siRNA, pDNA and other molecules by direct subcutaneous tumor injection (various tumor types)
- Efficiently deliver negatively charged biomolecules (DNA, RNA, small proteins) to specific organs in mice/rats. Transfection kits for animal laboratory research (mouse, rat)
- Track and detect cellular uptake (e.g. macrophages)
- Long cycle application
CD BioSciences is focused on developing In vivo delivery systems using our core technologies. With our high-quality products and services, your delivery effect will be greatly improved. If you can't find the perfect In vivo delivery system, you can contact us. We can provide one-to-one personal customization services.
Reference
- Tong S, et al.; Engineered materials for In vivo delivery of genome-editing machinery. Nat Rev Mater. 2019, 4:726-737.
