Dendrimer-Peptide Conjugation Service

Dendrimer binding to a peptide as a ligand enables targeted delivery of drugs. CD BioSciences has advanced facilities and experienced scientists to provide high quality peptide-conjugated dendrimers.

Ligands in Drug Delivery Systems

Targeted drug delivery systems are highly efficient and promising intelligent systems that are non-immunogenic, biocompatible, deliver drugs to specific tissues or organs and release specific amounts of drugs over a longer period, and are also suitable for both in vitro and in vivo drug delivery. Targeted drug delivery systems not only minimize drug damage to normal tissues, but also improve the bioavailability of drugs. In the preparation of targeted drug delivery systems, the surface properties and receptors of the target cells, the nature of the drug carriers and the appropriate ligands need to be considered. Target delivery can be achieved by passive or active strategies. Passive strategy involves loading the drug into the nanocarrier to achieve targeted delivery of the drug by enhancing drug permeability and retention (EPR) phenomenon. Passive drug delivery strategies involve coupling the drug-delivering nanocarrier to a specific ligand that can bind to a specific receptor on the surface of the diseased cell. Since many natural ligands can bind to a wide range of cell surface specific receptors, ligands are important in targeted drug delivery systems.

Dendrimer-Peptide Conjugation

Dendrimers are nanoscale, three-dimensional macromolecules with well-defined globular structures that hold promise for various aspects of gene and drug delivery due to their multivalent and host-guest entrapment properties. However, like other nanomaterials, dendrimers still have some drawbacks that can reduce the effectiveness of drug therapy, such as rapid clearance of dendrimers by the reticuloendothelial system, cytotoxicity from the interaction of amine terminated group with cell membrane and low transfection efficiency and lack of controlled release behavior, among others. To address these issues, surface functionalization of dendrimers can be carried out. Peptides are versatile and easy to prepare as ligands. When dendrimers are modified by peptides, i.e., linkage occurs, better targeting of drugs can be achieved. For example, when dendrimers bind to FSH they can selectively target FSHR for ovarian cancer treatment. When dendrimers bind to T7, they can easily enter cells with the help of transferrin, enhancing drug targeting to tumors while improving transfection efficiency. In addition, dendrimers can also bind to a variety of peptides such as LF, RGD and Pep-1.

Our Services

As a fast growing and leading global provider of scientific research services and solutions, CD BioSciences offers you dendrimer-peptide conjugation services. We are committed to meeting all your detailed requirements and guarantee that all deliverables are subjected to rigorous quality testing.

What We Provide

We offer you a variety of peptides to dendrimers conjugation services, including but not limited to:

Service Process

CD BioSciences is committed to helping our customers meet the growing and evolving demand for dendrimers products. We offer a wide range of services related to dendrimers and ensure quality and reliability of results as well as on-time delivery. If you are interested in our services or have any additional questions, please feel free to contact us, we are happy to hear from you and look forward to working with you.