Dendrimer-Glycopeptide Conjugation Service

Glycopeptides combined with dendrimers are widely used in biomedicine, where the antimicrobial effect is achieved by inhibiting the biofilm of bacteria. CD BioSciences has advanced facilities and experienced scientists to provide high quality dendrimer-glycopeptide conjugation services.

Dendrimer-Glycopeptide Conjugation

Dendrimers are synthetic nanoscale molecules with branched structures characterized by well-defined monodisperse molecules. The most common dendrimers are polyamide (PAMAM) dendrimers, which are commercially available in several generations, poly (propylene imine) dendrimers (PPI), and polyacrylimides. Dendrimers are suitable for multivalent display of chemical groups. When dendrimers are linked to glycopeptide containing carbohydrates (glycans), glycopeptide dendrimers contain only natural amino acids, are water soluble, and are good candidates for further development of antibiotic and drug conjugates.

Applications of Dendrimer-Glycopeptide Conjugation

As a nanoscale biomolecule, dendrimers themselves have multiple applications in biomedicine. The main applications of dendrimers when combined with glycopeptides are drug delivery and antibacterial.

• Drug Delivery

A particularly attractive potential application for dendrimers is drug delivery. Colchicine is a natural product that binds microtubule proteins and prevents their assembly during mitosis. Colchicine is not used for chemotherapy due to its cytotoxicity and would benefit from a vehicle capable of targeted drug delivery. The binding of dendrimers to glycopeptides is followed by intracellular degradation and release of active colchicine through cellular uptake, which can then bind to tubulin and greatly increase the inhibitory effect on HeLa cell proliferation.

• Antibacterial Effect

Bacterial biofilm formation is the formation of bacterial colonies attached to biological or non-biological surfaces that can create a physical barrier to antibiotics, thus making them resistant. The spread of drug-resistant bacteria is one of the most pressing problems facing human health today. When dendrimers are combined with glycopeptides, the antibacterial effect of drugs can be achieved by inhibiting the formation of biofilms of bacteria and reducing the formation of drug-resistant bacteria.

Our Services

As a fast growing and leading global provider of scientific research services and solutions, CD BioSciences offers you dendrimer-glycopeptide conjugation services. We are committed to meeting all your detailed requirements and guarantee that all deliverables are subjected to rigorous quality testing.

Service Process

CD BioSciences is committed to helping our customers meet the growing and evolving demand for dendrimers products. We offer a wide range of services related to dendrimers and ensure quality and reliability of results as well as on-time delivery. If you are interested in our services or have any additional questions, please feel free to contact us, we are happy to hear from you and look forward to working with you.