Dendrimer-Tuftsin Conjugation Service

Tuftsin-conjugated dendrimers can target HIV, with improved chemotherapy efficacy and reduced drug toxicity. With advanced technology and powerful tools, CD BioSciences is confident that we can help our customers solve any problems they encounter in their dendrimer modification programs and turn breakthrough ideas into reality.

Immunomodulatory Effects of Tuftsin

Immunomodulation includes the stimulation and suppression of the immune system by various substances called immunomodulators, designed to modulate the body's immune response to different etiologies, and is an important therapeutic strategy. As an immunomodulator, tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg, TKPR) located in the Fc structural domain of the immunoglobulin G heavy chain (residues 289-292). Tuftsin is involved in a variety of biological functions related to the immune system and has broad-spectrum immune activities such as migration, phagocytosis, bactericidal, and tumor suppression. Due to structural similarities, tuftsin binds specifically to macrophages, monocytes and polymorphonuclear leukocytes. In addition, tuftsin alleviates symptoms, raises blood pressure, and inhibits lymphatic vasoconstriction.

Dendrimer-Tuftsin Conjugation for Targeted Treatment of Cancer

Dendrimers are a class of polymers with nanoscale structures that are mainly used in biomedical applications. There are several types of dendrimers, among which poly(propyleni-mine) (PPI) dendrimers are promising three-dimensional polymers for pharmaceutical and biomedical applications, generally characterized by the presence of primary amine terminal groups and tertiary propylene amines inside the PPI structure. The main mechanism of action of PPI dendrimers is to increase the solubility of conjugated drugs through electrostatic interactions, and their main advantages include easy surface modification, allowing for high-substituted dendrimers, and drug delivery versatility and high functionality. When PPI dendrimers are bound to tuftsin, tuftsin can specifically bind to macrophages, monocytes and polymorphonuclear leukocytes due to structural similarities. In addition, tuftsin shields the cationic moiety of the dendrimers and reduces cytotoxicity. Therefore, when dendrimers are conjugated with tuftsin, they play an important role in HIV-targeted therapy, improving the efficacy of tumor chemotherapy and reducing systemic drug toxicity.

Our Services

CD BioSciences is a leading biotechnology company with the expertise and capability to provide dendrimer modification services to customers worldwide. With advanced technology and experienced scientists, CD BioSciences is proud to provide you with dendrimer-tuftsin conjugation services. Our goal is to provide you with the highest quality dendrimer-tuftsin modification services with a fast turnaround time, in a timely and professional manner to ensure your satisfaction.

Application

Why Choose Us?

• We have a well-established and proven technology platform to help our customers break through all the barriers of dendritic macromolecule research projects.
• We have high quality organic chemistry reagents and dendrimer products to meet all the needs of our customers worldwide.
• We have experienced experts in the field of organic chemistry to provide you with the most effective and high-quality solutions.

Want to Learn More?

Throughout the years, CD BioSciences has focused on developing services and products for a wide range of steps in the dendrimer modification workflow. To get started on your dendrimer modification project, please feel free to contact us for more details. Our experienced scientists and R&D team will meet each of your specific requirements and help you solve any problems you may encounter, and we look forward to working with your attractive projects.