Drug Delivery System Development Service

Dendrimers are highly branched, synthetic macromolecules with a well-defined structure and size that have been extensively studied for their potential in drug delivery applications. With extensive experience in the development of dendrimer products, CD BioSciences is proud to introduce our professional services in the development of dendrimers for drug delivery with our diverse technologies. Our highly trained, friendly, and professional Learning Directors and Project Managers strive to complete your project on time and through the communication channels we have developed.

Introduction into Drug Delivery System

A drug delivery system refers to the methods or technologies used to transport a therapeutic agent (drug) to its target site within the body. The goal of drug delivery systems is to improve the efficacy and safety of drugs by controlling their release rate, targeting specific cells or tissues, and reducing toxicity to healthy tissues. There are several types of drug delivery systems, including:

Advantages of Dendrimers as Drug Delivery Systems

• Improving Drug Solubility and Utilization
  One of the key advantages of dendrimers as drug delivery vehicles is their ability to improve drug solubility and bioavailability. Dendrimers can encapsulate these drugs within their interior cavities or on their surface, increasing their solubility and allowing for improved drug delivery. Furthermore, dendrimers can protect drugs from degradation or clearance by the body's immune system, increasing their bioavailability.
• Improving Drug Targeting
  Another important feature of dendrimers is their ability to target specific cells or tissues. Dendrimers can be functionalized with various targeting ligands such as antibodies, peptides, or small molecules that can recognize and bind to specific receptors on the surface of target cells. This allows for selective drug delivery to diseased cells, while minimizing off-target effects on healthy tissues. Additionally, dendrimers can penetrate cellular carriers such as the blood-brain barrier or tumor vasculature, allowing for improved delivery of drugs to these sites.
• Promoting Controlled Release of Drugs
  Dendrimers can also be used to promote controlled drug release. By modifying the dendrimer surface with responsive or stimuli-sensitive groups, drug release can be triggered by changes in the environment such as pH, temperature, or enzyme activity. This allows for precise control over the timing and location of drug release, which can improve drug efficacy and reduce side effects.

Schematic illustration of biodegradable dendrimers as drug carriers. (Huang D, Wu D. 2018)

Development of Dendrimers for Drug Delivery

Dendrimers have been developed for a variety of drug delivery applications, including cancer therapy, gene therapy, and imaging. For example, dendrimers have been used to deliver chemotherapeutic agents to tumor cells, improving their efficacy and reducing systemic toxicity. Additionally, dendrimers have been used as carriers for siRNA, a promising tool for gene therapy. Despite their promise, there are still challenges associated with the development of dendrimers for drug delivery. These challenges include improving dendrimer stability, optimizing their pharmacokinetic properties, and reducing toxicity. However, continued research and development in this field may lead to the use of dendrimers in a wide range of therapeutic applications.

Our Services

As an industry leader specializing in the development of dendrimer products, CD BioSciences is committed to developing novel dendrimer products and our experienced scientists are happy to help you with the difficulties of developing dendrimer projects for drug delivery. Our services include but are not limited to.

Why Choose Us?

• Professional knowledge and advanced technology platform
• Experienced and expert level scientists
• Innovative products and high-quality, hassle-free, cost-effective services
• Fast turnaround time

Want to Learn More?

A wealth of experience and state-of-the-art technology, all of which ensure that CD BioSciences provides high-quality customized services for your dendrimer research projects. We also have an innovative range of dendrimer products to meet your diverse needs. If you are interested in our services or have any additional questions, please feel free to contact us.

Reference

1. Huang D, Wu D. Biodegradable dendrimers for drug delivery. Mater Sci Eng C Mater Biol Appl. 2018, 90: 713-727.