Transdermal Drug Delivery System Development Service

Dendrimers are a promising platform for transdermal drug delivery due to their unique properties such as high solubility, low toxicity, and biocompatibility. They can encapsulate drugs and release them in a controlled manner, making them suitable for transdermal drug delivery. CD BioSciences is a world leading CRO specializing in dendrimer product development services. We are known for our expertise in the redevelopment, performance, and manufacture of effective, safe, and robust dendrimer transdermal agents. Our extensive knowledge has been developed from our 20 years of expertise in transdermal development.

Introduction into Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) are medical devices that enable drugs to be administered through the skin and into the bloodstream, providing a non-invasive alternative to traditional routes of drug administration, such as oral or intravenous routes. The skin is a highly effective barrier that protects the body from external agents. However, it is also capable of absorbing certain molecules, which makes it a valuable site for drug delivery. Transdermal drug delivery systems consist of a patch or adhesive that contains the drug, which is designed to deliver the drug through the skin over a prolonged period of time. TDDS offer several advantages over other drug delivery methods, such as improved patient compliance, reduced side effects, and sustained drug delivery. They are used to deliver a wide range of drugs, including hormones, pain relievers, and cardiovascular medications. However, not all drugs can be delivered through the skin, as some molecules are too large to be absorbed. In addition, TDDS can cause skin irritation, and there may be limitations in the amount of drug that can be delivered through this route.

Process of Dendrimer Development for Transdermal Drug Delivery

The development of dendrimers for transdermal drug delivery systems involves several steps. Here is a general process for their development:

• Design
  The first step in developing dendrimers for transdermal drug delivery is to design a dendrimer that is appropriate for the drug being delivered. This involves selecting the appropriate size, charge, and surface functionality of the dendrimer to allow for efficient penetration into the skin.
• Synthesis
  The next step is to synthesize the dendrimer using appropriate chemistry. This can involve a variety of techniques, such as step-wise growth, convergent synthesis, or divergent synthesis.
• Characterization
  Once the dendrimer is synthesized, it needs to be characterized to ensure that it meets the desired specifications. Characterization techniques can include size and charge measurements, as well as structural analysis using techniques such as NMR spectroscopy or X-ray crystallography.
• Drug Loading
  The drug that is to be delivered needs to be loaded onto the dendrimer. This can be achieved using a variety of techniques, such as covalent attachment or non-covalent encapsulation.
• Formulation
  The dendrimer-drug complex needs to be formulated into a transdermal delivery system. This can involve incorporating the complex into a topical cream, patch, or other delivery system that is appropriate for transdermal delivery.
• In Vitro and in Vivo Evaluation
  The transdermal delivery system needs to be evaluated in vitro and in vivo to determine its efficacy and safety. In vitro evaluation can involve assessing the release of the drug from the dendrimer complex, as well as its ability to penetrate the skin. In vivo evaluation can involve assessing the pharmacokinetics and pharmacodynamics of the drug, as well as its safety and tolerability.
• Optimization
  Based on the results of the in vitro and in vivo evaluations, the dendrimer transdermal delivery system may need to be optimized. This can involve adjusting the size, charge, or surface functionality of the dendrimer, or altering the formulation of the delivery system.

Synthesis scheme of peptide dendrimer conjugates of ketoprofen that can be used as transdermal drug delivery system. (Hegde AR, et al., 2017)

Our Services

CD BioSciences is a leader in the development of novel dendrimers. We have extensive experience with novel dendrimer systems for drug delivery, such as transdermal drug delivery systems, nebulized drug delivery systems, and ocular drug delivery systems. Our experienced scientists are committed to providing you with cost-effective dendrimers for transdermal drug delivery and to meeting your specific needs.

Advantages of CD BioSciences

• Decades of experience in the development of new dendrimer products
• Dedicated scientists, advanced technology platform and sophisticated instrumentation
• High-quality, hassle-free, cost effective customization
• Fast turnaround time

Want to Learn More?

In addition to our world-class dendrimer products, CD BioSciences offers services for engineering and characterization assays for dendrimers. All of our deliverables are subject to rigorous quality testing and are delivered on time. Please feel free to contact us for more details and we look forward to working with you on your attractive projects.

Reference

1. Hegde AR, et al., Peptide dendrimer-conjugates of ketoprofen: Synthesis and ex vivo and in vivo evaluations of passive diffusion, sonophoresis and iontophoresis for skin delivery. Eur J Pharm Sci. 2017, 102: 237-249.