Mucosal Drug Delivery System Development Service

Dendrimers are highly branched, nanoscale polymers that have been investigated for their potential as drug delivery systems for mucosal surfaces. Mucosal surfaces are found throughout the body, including the respiratory, gastrointestinal, and urogenital tracts, and represent an attractive target for drug delivery due to their large surface area, high permeability, and low enzymatic activity. CD BioSciences is a world leading CRO specializing in dendrimer product development services, and our scientists have extensive experience in developing dendrimer macromolecule products targeting the mucosal pathway.

Introduction into Mucosal Drug Delivery System

Mucosal drug delivery system refers to the administration of drugs through the mucosal membranes of the body, such as the nasal, oral, pulmonary, vaginal, and rectal routes. This method of drug delivery offers several advantages over traditional delivery methods, such as oral or injectable routes, including faster onset of action, improved bioavailability, reduced systemic side effects, and increased patient compliance. The mucosal surfaces of the body provide an excellent site for drug delivery due to their large surface area and high permeability. Mucosal surfaces are covered with a layer of mucus that acts as a protective barrier and helps in the absorption of drugs. Various techniques are employed to enhance the bioavailability of drugs delivered through mucosal routes, including the use of permeation enhancers, mucoadhesive agents, and particulate drug delivery systems. For example, the use of nanoparticles can increase the residence time of the drug at the site of absorption, leading to improved drug delivery and therapeutic outcomes. Mucosal drug delivery systems have been used to deliver a wide range of drugs, including vaccines, hormones, and antibiotics. The nasal route of drug delivery has been used for the treatment of migraine headaches, while the pulmonary route has been used for the treatment of respiratory diseases such as asthma.

Dendrimers for Mucosal Drug Delivery

Dendrimers have been investigated for drug delivery to a variety of mucosal surfaces, including:

• Respiratory Tract
  Dendrimers have been investigated for the delivery of drugs to the lungs for the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
• Gastrointestinal Tract
  Dendrimers have been used for drug delivery to the gastrointestinal tract, including the oral and rectal routes, for the treatment of diseases such as inflammatory bowel disease (IBD).
• Urogenital Tract
  Dendrimers have been investigated for the delivery of drugs to the vaginal and urethral mucosa for the treatment of infections and other diseases.

Advantages of mucoadhesive polymer-encrusted dendrimeric system over dendrimer-loaded carrier system. (Raval N, et al., 2019)

Our Services

CD BioSciences has extensive experience in the development of novel dendrimers and is committed to serving you with dendrimers for mucosal drug delivery. With our expertise in organic chemistry and advanced technology platform, we will work with you to develop the most appropriate strategy to meet your specific needs.

Why Choose Us?

• Excellent Facilities: CD BioSciences has excellent facilities to support dedicated scientists to help carry out your attractive projects.
• Professional Knowledge: With professional knowledge in organic chemistry and nanomaterials, CD BioSciences is confident that we can help you develop dendrimer systems for mucosal drug delivery.
• Advanced Technology Platform: At CD BioSciences, we have built an advanced technology platform to address each of your specific needs.
• Proven Experience: Having focused on dendrimer research for many years, CD BioSciences has the experience to help you overcome all the difficulties in carrying out your project.
• Successful Partnership: CD BioSciences has successfully partnered with and gained the trust of hundreds of passionate researchers around the world.

Want to Learn More?

CD BioSciences is a leader in dendrimer research, providing you with innovative dendrimer products and custom services, including engineering and characterization assays. All of our deliverables are subject to rigorous quality testing and are delivered on time. If you are interested in our services or have any other questions, please feel free to contact us for more details.

Reference

1. Hegde AR, et al., Peptide dendrimer-conjugates of ketoprofen: Synthesis and ex vivo and in vivo evaluations of passive diffusion, sonophoresis and iontophoresis for skin delivery. Eur J Pharm Sci. 2017, 102: 237-249.