Dendrimer-Small Molecule Conjugation Service

The functionalization of dendrimers with small molecules breaks down the limitations when used as delivery vehicles and allows for a broader range of biomedical applications. As experts in providing dendrimer functionalization services and product development, CD BioSciences integrates emerging technologies and expertise into our proprietary technology platform. Our talented scientists are confident that we can meet each of your specific requirements and provide you with high quality dendrimer-small molecule conjugation services.

Dendrimer As Delivery Vectors

Dendrimers are nano-sized three-dimensional polymers with a well-defined spherical structure. They are widely used for drug and gene delivery due to their multivalent and host-guest entrapment properties. However, like other nanomaterials, dendrimers have disadvantages such as rapid clearance by the reticuloendothelial system, toxicity due to the interaction of telomeric groups with cell membranes, low transfection efficiency and lack of controlled release behavior, which reduce the therapeutic efficacy of drugs. When dendrimers are modified by small molecules (e.g., folic acid, biotin, amino acids and cyclodextrins), the shortcomings of dendrimers as delivery vehicles can be effectively solved, not only increasing the efficiency of gene transfection, but also reducing cytotoxicity and even increasing the targeting of drugs.

Advantages of Dendrimer-Small Molecule Conjugation

As a nanomaterial, dendrimers have a monodisperse three-dimensional structure with many functional groups on the surface that can be conjugated or anchored to different ligands, and in addition, the biocompatibility of dendrimers makes them a potential drug delivery system. When dendrimers are modified with folic acid and used as delivery carriers, they can increase the targeting of delivered substances for cancer diagnosis and treatment. Dendrimers exhibit higher tissue specificity and cellular uptake when conjugated with biotin. To further improve transfection efficiency, dendrimers can be functionalized with ligands such as cyclodextrins, lipids, glycans, peptides, fluorine compounds, nanoparticles, and amino acids. Dendrimers can be modified by amino acids through simple condensation reactions to increase transfection efficiency. In addition, the solubility, stability, and biocompatibility of dendrimers are improved when they are conjugated with cyclodextrins.

Dendrimer conjugated to cationic amino acids increase cellular uptake and endosomal escape. (Ghaffari M, et al., 2018)

Our Services

With expertise and experience in dendrimers, CD BioSciences is committed to providing dendrimer-small molecule conjugation services to customers worldwide to help them realize the tremendous potential of dendrimers in a variety of applications. Our distinguished scientists are dedicated to providing customized solutions to meet your specific needs and overcome all the difficulties of your dendrimer product development and application. The services we can provide are listed below.

Why Choose CD BioSciences?

• World-class R&D team
• Standards-compliant facilities and skilled laboratory personnel
• Extensive experience in engineering and product development of dendrimers
• Comprehensive research tracking and technical support

Want to Learn More?

As a fast-growing biotechnology company, CD BioSciences has innovative dendrimer products and high-quality services. We are committed to providing you with cost-effective, hassle-free custom services and solutions regarding dendrimers that increase applications of dendrimers in biology. All our deliverables are subjected to rigorous quality testing and delivered with fast turnaround times. If you are interested in our services or products, please feel free to contact us.

Reference

1. Ghaffari M, et al., Surface functionalized dendrimers as controlled-release delivery nanosystems for tumor targeting. Eur J Pharm Sci. 2018, 122: 311-330.