Dendrimer-Cyclodextrin Conjugation Service

Dendrimers, when functionalized by cyclodextrins, not only improve gene transfection efficiency but also increase drug targeting when used as delivery vectors. CD BioSciences integrates emerging technologies and advanced tools into our dendrimer engineering platform to break the limitations of dendrimer applications and help our customers develop dendrimer products for a wider range of applications. With our experienced scientists and expertise, we are confident that we can provide you with the highest quality dendrimer-cyclodextrin conjugation services.

Introduction into Cyclodextrins

Chemical structure of α-cyclodextrin, β- cyclodextrin, γ-cyclodextrin. (Arima H., 2021)

As an oligosaccharide, cyclodextrins (abbreviated CDs) are produced from starch by an enzymatic reaction and are sugar molecules bound together in rings of different sizes, specifically these sugar units are known as glucopyranosides. They are used in food, pharmaceutical, drug delivery, chemical industry, agriculture, and environmental engineering. Cyclodextrins consist of six or more glucose units linked by α-1,4-glucosidic bonds. Typical cyclodextrins contain 6, 7 or 8 glucose units, named α-, β- and γ-cyclodextrin, respectively, and are generally regarded as safe. Among them, β- cyclodextrins are the most studied and most frequently used due to their low cost, availability, and their ability to encapsulate a wide range of molecules in their inner lumen. Cyclodextrins are often used as enhancers of gene and drug delivery, protect oligonucleotides from nucleases, and facilitate endosomal escape of pDNA complexes after cellular uptake. In addition, the variable reactivity of hydroxyl groups and remarkable encapsulation properties can improve the physical, chemical, and biological properties of host molecules, making cyclodextrins perfect candidates for the construction of drug delivery systems.

Dendrimer-Cyclodextrin Conjugation as Delivery Vectors

Nanomedicine has shown great potential for drug delivery and targeted release due to its ability to improve safety by reducing off-target organ delivery and toxicity to tissues. As a nanomaterial, dendrimers have many unique properties, such as monodispersity, many functional groups on the surface, and an excellent ability to encapsulate host molecules in a hydrophobic environment, making them ideal nanocarriers for targeted delivery of therapeutic and diagnostic drugs. Cyclodextrins have hydrophobic interiors and hydrophilic exteriors and can form complexes with hydrophilic compounds. When dendrimers are conjugated with cyclodextrins, cyclodextrins can confer higher solubility and stability to drugs, and their internal cavities can encapsulate various lipid molecules (cholesterol, bile acids, etc.) to improve the affinity to cell membranes. In addition, the solubility, stability, and biocompatibility of dendrimers can be improved. Therefore, dendrimers are excellent drug delivery and gene delivery carriers when conjugated with cyclodextrins.

Scheme for preparation of α-CD-dendrimer, β-CD-dendrimer, and γ-CD-dendrimer. (Arima H., 2021)

Our Services

As a trusted custom service provider, CD BioSciences offers dendrimer-cyclodextrin conjugation services to customers worldwide to help realize a wide range of applications for dendrimers. We are committed to providing high quality, hassle-free customization services to help our customers solve all problems encountered in the functionalization of dendrimers. Our distinguished scientists will meet each of your specific needs and deliver results with fast turnaround times.

• Dendrimer-α-cyclodextrin Conjugation
• Dendrimer-β-cyclodextrin Conjugation
• Dendrimer-γ-cyclodextrin Conjugation

Why Choose CD BioSciences?

Rich experience and solid teamwork

Mature technology platform and controlled development process

Flexible solutions and comprehensive validation and optimization

Cost effective and fast turnaround

Want to Learn More?

As experts in the engineering and products development of dendrimers, CD BioSciences leverages expertise and experience to provide you with high-quality, customized services to meet the growing demand for them in the biomedical field. We guarantee that all deliverables will undergo rigorous quality testing. If you are interested in our services or have any other questions, please feel free to contact us and we look forward to working with you on your attractive projects.

Reference

1. Arima H. Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers. Pharmaceutics. 2021, 13: 697.