Dendrimer-Biotin Conjugation Service

Dendrimer modified with biotin can be used as drug delivery vehicles for more precise delivery of anti-cancer drugs for cancer treatment. As a rapidly growing biotechnology company, CD BioSciences has built a robust organic chemistry platform for dendrimer modification and innovative product development and is leading the way to sustainable manufacturing. Our experienced scientists can help our customers develop effective dendrimer modification strategies, including dendrimer-biotin conjugation services, to meet the growing global demand for dendrimers.

Introduction into Biotin

Biotin, also known as vitamin B7 or vitamin H, belongs to the B vitamin group. Biotin is a growth promoter for cells and is used as a coenzyme for fatty acid biosynthesis and glycoisomerization, which are essential for normal cell function. The rapid growth and proliferation of cancer cells results in an additional demand for biotin uptake compared to normal cell growth, which results in more biotin receptors on the surface of cancer cells than in normal tissues. Biotin overexpression is widely present in a variety of cancer cells, including kidney, lung, ovarian, breast, and other cancer cell lines. Therefore, biotin is widely used in pharmacological research due to its low molecular weight, relatively simple biochemical structure, and high tumor specificity. Cancer cells require higher levels of biotin due to their high metabolic activity, and therefore biotin receptors are overexpressed in many cancer cells. Biotin receptors are overexpressed by various types of solid cancer cells, play an important role in tumor metabolism, growth, and metastasis, and are biomarkers for targeting cancer cells. Due to this property, biotin has become an important active targeting component of drug nanocarriers.

Dendrimer-Biotin Conjugation for Anti-cancer Drug Targeted Delivery

Nanocarriers have enhanced permeability and retention (EPR) effects due to their large size and poor vascular leakage and lymphatic clearance within the tumor. The deleterious effect of anticancer drugs on normal tissues is a major obstacle to their clinical application. The efficacy and tolerability of anticancer drugs can be improved by using specific targeted drug delivery systems that effectively limit side effects. Due to the specific interaction of biotin and its receptors, many nanocarriers coupled with biotin have been developed to enhance the targeting of anticancer drugs. As a nanomaterial, dendrimers have a monodisperse three-dimensional structure and many functional groups on the surface that can be conjugated or anchored to different ligands, in addition to the biocompatibility of dendrimers, which makes them a potential drug delivery system. When dendrimers bind to biotin, they can target biotin receptors on tumor cells to improve the efficiency of chemotherapy and reduce side effects. Dendrimers coupled with biotin can exhibit higher tissue specificity and cellular uptake through biotin receptor-mediated endocytosis. In addition, the low molecular weight of biotin reduces the spatial site block during the reaction.

Schematic representation of the mechanism of action of PG4.5-DETA-biotin/GEM nanoparticles. (Hanurry EY, et al., 2020)

Our Services

As a fast-growing and customer-focused biotechnology company, CD BioSciences focuses on dendrimer modification services to meet market demand trends for dendrimers. We are committed to meeting our customers' needs in an environmentally sustainable and cost-effective manner and are proud to provide cost-effective dendrimer-biotin conjugation services to our customers worldwide.

Why Choose Us?

Want to Learn More?

As a fast-growing CRO, CD BioSciences is committed to dendrimer modification and products development to meet the growing and evolving needs of our customers for dendrimer macromolecules. All our deliverables will undergo a rigorous quality testing process to ensure quality and reliability. We will attack the challenges of your project with the fastest turnaround time to meet all your detailed needs. If you are interested in our services or have any other questions, please feel free to contact us.

Reference

1. Hanurry EY, et al., Biotin-Decorated PAMAM G4.5 Dendrimer Nanoparticles to Enhance the Delivery, Anti-Proliferative, and Apoptotic Effects of Chemotherapeutic Drug in Cancer Cells. Pharmaceutics. 2020, 12: 443.