Small Molecule Drug Delivery

Dendrimers are highly branched, well-defined, and monodisperse macromolecules that have been widely explored as drug delivery vehicles due to their unique structural properties, such as a high number of functional groups on their surface and a well-defined size and shape. Dendrimers can be synthesized with a variety of core and surface chemistries, making them versatile platforms for drug delivery.

Nanomaterials for Small Molecule Drug Delivery

Small molecule drug delivery refers to the process of delivering therapeutic molecules that are small to their intended targets in the body. Small molecules are organic compounds that have a molecular weight of less than 900 Da and can easily penetrate cell membranes. Nanomaterials have shown great potential in the field of drug delivery due to their unique physicochemical properties, such as their small size and large surface area to volume ratio. Here are some examples of nanomaterials that are commonly used for small molecule drug delivery:

• Liposomes
  Liposomes are spherical, self-assembled vesicles composed of a phospholipid bilayer membrane. Small molecule drugs can be encapsulated within the aqueous core or lipid bilayer of liposomes, allowing for controlled release and improved pharmacokinetics.
• Polymeric Nanoparticles
  Polymeric nanoparticles are typically composed of biodegradable polymers such as poly (lactic-co-glycolic acid) (PLGA) or polyethylene glycol (PEG). These particles can be loaded with small molecule drugs through a variety of methods, such as emulsion or solvent evaporation techniques.
• Carbon Nanotubes
  Carbon nanotubes are cylindrical structures composed of carbon atoms. Small molecule drugs can be loaded onto the surface of carbon nanotubes or encapsulated within their hollow interior, allowing for targeted drug delivery to cells or tissues.
• Dendrimers
  Dendrimers are highly branched, monodisperse polymers with a central core and numerous peripheral branches. Small molecule drugs can be encapsulated within the internal cavities of dendrimers or attached to the surface of the branches, allowing for precise control over drug loading and release.

Dendrimers for Small Molecule Drug Delivery

Dendrimers are highly branched, well-defined, and monodisperse macromolecules that have been widely explored as drug delivery vehicles due to their unique structural properties, such as a high number of functional groups on their surface and a well-defined size and shape. Dendrimers can be synthesized with a variety of core and surface chemistries, making them versatile platforms for drug delivery. Small molecule drug delivery using dendrimers typically involves the encapsulation of the drug within the dendrimer core or attachment of the drug to the dendrimer surface through covalent or non-covalent interactions. The encapsulation of drugs within the dendrimer core can improve drug solubility, stability, and bioavailability, while surface modification of dendrimers can enhance drug targeting and reduce toxicity. With these advantages, dendrimers hold immense potential as promising carriers for diverse small molecule drugs, contributing to advancements in drug delivery and therapeutic efficacy.

How We Can Help

At CD BioSciences, we focus on providing innovative dendrimer products and high-quality, hassle-free, cost-effective customization services to meet each of our customers' specific needs. Our dedicated scientists are confident that all challenges in dendrimer research projects will be broken through, and all deliverables will be rigorously tested for quality and delivered on time. If you are interested in our products or services or have any other questions, please feel free to contact us.

Reference

1. Chis AA.; et al. Applications and Limitations of Dendrimers in Biomedicine. Molecules. 2020, 25: 3982.