Anti-inflammatory Agents Delivery

Anti-inflammatory agents are widely used to treat various inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and asthma. However, the systemic administration of these drugs often leads to unwanted side effects such as gastrointestinal bleeding, renal toxicity, and immunosuppression. Therefore, the targeted delivery of anti-inflammatory drugs using dendrimers can potentially minimize the side effects and improve the therapeutic efficacy.

Systems for the Delivery of Anti-inflammatory Agents

A variety of drug delivery systems are available for anti-inflammatory agent delivery, each with its own advantages and disadvantages. Some of the common systems used for anti-inflammatory agent delivery are listed below:

• Liposomes
  Liposomes have been extensively studied for the delivery of anti-inflammatory drugs, such as corticosteroids, and have shown promising results in various animal models of inflammation.
• Polymeric Nanoparticles
  Polymeric nanoparticles are made up of biodegradable polymers such as poly (lactic-co-glycolic acid) (PLGA) and can be functionalized with various ligands for targeted delivery. Polymeric nanoparticles have been studied for the delivery of anti-inflammatory drugs, such as NSAIDs, and have shown promising results in various animal models of inflammation.
• Micelles
  Micelles are spherical aggregates of amphiphilic molecules that can encapsulate drugs and protect them from degradation. Micelles have been studied for the delivery of anti-inflammatory drugs, such as NSAIDs, and have shown promising results in various animal models of inflammation.
• Hydrogels
  Hydrogels are three-dimensional networks of hydrophilic polymers that can encapsulate drugs and release them in a controlled manner.
• Dendrimers
  Dendrimers are highly branched, tree-like macromolecules that have emerged as promising drug delivery systems due to their unique properties such as their nanoscale size, well-defined structure, and tunable surface functionality. They have been extensively studied for the delivery of various drugs, including anti-inflammatory agents.

Dendrimers for Anti-inflammatory Agents Delivery

Dendrimers can be functionalized with various targeting ligands, such as antibodies or peptides, which can selectively bind to the inflamed tissue and deliver the drug specifically to the site of inflammation. Moreover, the surface of dendrimers can be modified with different chemical groups to control the release rate of the drug and enhance its stability in the bloodstream. Several studies have demonstrated the potential of dendrimers for the delivery of anti-inflammatory agents such as dexamethasone, ibuprofen, and indomethacin. For instance, PEGylated dendrimers have been shown to improve the therapeutic efficacy of dexamethasone in a mouse model of rheumatoid arthritis. Similarly, indomethacin-loaded dendrimers have been shown to have a higher anti-inflammatory activity than free indomethacin in a rat model of inflammation.

Schematic diagram of a dendrimer delivering an anti-inflammatory agent (aspirin). (Abd-El-Aziz AS, et al., 2021)

With a dedicated team and experienced scientists at CD BioSciences, we are confident that we can provide you with dendrimer-anti-inflammatory agents conjugation services for the treatment of inflammatory diseases.

How We Can Help

As a fast-growing CRO with extensive expertise and experience in dendrimer research, CD BioSciences is confident in providing innovative dendrimer products and high-quality, hassle-free, cost-effective customized services regarding dendrimer research to our global customers. Our dedicated, highly trained scientists will meet each of your specific requirements. All of our deliverables will undergo rigorous quality testing and be delivered on time. If you are interested in our products or services or have any additional questions, please feel free to contact us. We look forward to working with you on your attractive project.

Reference

1. Abd-El-Aziz AS.; et al. Aspirin-Based Organoiron Dendrimers as Promising Anti-Inflammatory, Anticancer, and Antimicrobial Drugs. Biomolecules. 2021, 11: 1568.