Nebulized Drug Delivery

Dendrimers are a promising class of materials for nebulized drug delivery. Dendrimers are highly branched, nanoscale polymers with a well-defined structure and a high surface area-to-volume ratio. These properties make dendrimers attractive candidates for drug delivery because they can encapsulate or attach various molecules, including drugs, and improve their solubility, stability, and bioavailability.

Nebulized Drug Delivery Enables Effective and Convenient Delivery of Drugs to Lungs

Nebulized drug delivery is an effective and convenient method of delivering drugs directly to the lungs and is an important part of the treatment of respiratory diseases. This method is commonly used to treat respiratory diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Nebulized drug delivery has several advantages over other methods of drug delivery, including:

• Targeted Delivery
  Nebulized drug delivery delivers medication directly to the lungs, where it is needed most, and can therefore provide a more targeted and effective treatment for respiratory diseases.
• Rapid Action
  Nebulized drugs are delivered directly to the lungs and can therefore act quickly to relieve symptoms.
• Lower Doses
  Nebulized drug delivery allows for lower doses of medication to be used, which can reduce the risk of side effects and minimize the amount of medication that is absorbed into the bloodstream.
• Convenient
  Nebulizers are easy to use and can be used at home or in a healthcare setting, which can be more convenient for patients than other methods of drug delivery.
• Flexible
  Nebulized drug delivery can be used to deliver a wide range of medications, including antibiotics, bronchodilators, and corticosteroids.
• Safe
  Nebulized drug delivery is generally considered safe and is suitable for use in children and elderly patients.

Dendrimers are Suitable for Nebulized Drug Delivery

Dendrimers are highly branched, spherical, and nanoscale polymers that have unique properties, including a high surface area-to-volume ratio, well-defined structure, and the ability to encapsulate or attach various molecules. Due to their properties, dendrimers have shown promise as carriers for drug delivery applications, including nebulized drug delivery. Dendrimers have several properties that make them attractive for nebulized drug delivery, including:

• Small Size
  Dendrimers are typically less than 10 nm in diameter, which makes them small enough to penetrate the airways and reach the lungs.
• High Surface Area
  Dendrimers have a high surface area-to-volume ratio, which allows them to carry a large amount of drug molecules.
• Targeting Ability
  Dendrimers can be functionalized with targeting moieties, such as antibodies or peptides, that can bind to specific receptors on lung cells. This can improve the specificity and efficiency of drug delivery.
• Stability
  Dendrimers are highly stable and can protect drug molecules from degradation, which can improve the effectiveness of nebulized drug delivery.

TPP-dendrimer nanocarriers for siRNA delivery to the pulmonary epithelium and their dry powder and metered-dose inhaler. (Bielski E, et al., 2017)

As a fast-growing custom service provider specializing in dendrimer research, CD BioSciences is dedicated to helping you develop dendrimers for mucosal drug delivery.

How We Can Help

CD BioSciences is pleased to share our cutting-edge technology and extensive expertise in the development and engineering of dendrimers with passionate researchers around the world and has always focused on dendrimer research. We can tailor our solutions to meet each client's most specific requirements, thus providing a high quality, cost effective, hassle-free, and customized service. If you need assistance in this area, please contact us for more details.

Reference

1. Bielski E.; Woo SJ. TPP-dendrimer nanocarriers for siRNA delivery to the pulmonary epithelium and their dry powder and metered-dose inhaler formulations. Int J Pharm. 2017, 527: 171-183.