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WTX Antibody
SPA-11835
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | WTX |
| Gene Abbr. | AMER1 |
| Gene ID | 139285 |
| Full Name | APC membrane recruitment protein 1 |
| Alias | FAM123B, OSCS, WTX |
| Introduction | WTX (Wilms’ tumor gene on the X chromosome) is a developmentally regulated gene with a potentially important role in kidney development. Functional studies of WTX suggest that it acts as a tumor suppressor gene in renal cells by promoting β-catenin ubiquitination and degradation, thereby antagonizing WNT/β-catenin signaling. WTX is found to be inactivated in 30% of Wilms’ tumors, mostly by chromosomal deletion. Wilms’ tumor is a pediatric kidney cancer that arises from cells that fail to differentiate during kidney development. Inactivation of the WT1 tumor suppressor gene accounts for 10-15% of Wilms’ tumor cases. WTX has been shown to enhance WT1-mediated transactivation, suggesting a physiologically significant interaction between WT1 and WTX. WTX may be directly involved in the transcriptional regulation of cellular differentiation in the kidney through interactions with WT1 and other transcription factors. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | D38E5 |
| Immunogen | Recombinant protein specific to the amino terminus of human WTX protein. |
| Source/Purification | Antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human WTX protein. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (1:1000) |
| MW(KDa) | 200 |
| Reactivity | Human |
| Sensitivity | Transfected Only |
| Specificity | It detects transfected levels of total WTX protein. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. |
| Preservative | Less than 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.