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WRN Knockout Cell Line
SPL-04008
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| 17p deletion |
| Target Information | |
|---|---|
| Target Name | WRN |
| Gene Abbr. | WRN |
| Gene ID | 7486 |
| Full Name | WRN RecQ like helicase |
| Alias | RECQ3, RECQL2, RECQL3 |
| Species | Human |
| Genomic Locus | chr8:31058479 |
| Introduction | This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]. |
| Product Details | |
|---|---|
| Cell Line Model | HAP1 |
| Genotype | WRN 17bp deletion knockout |
| Description | 17p deletion |
| Parental Cell Line | C631 |
| Handling Specifications | |
|---|---|
| Culture Medium | IMDM + 10% FBS |
| Disclaimer | This product is classified under IATA regulations as a GMMO (genetically modified micro-organism) and will ship as UN3245. If applicable, ensure facility meets all requirements per local and country regulations. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.