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WHSC1 (+/-) Cell Line
SPL-02350
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| WHSC1 (+/-) |
| Target Information | |
|---|---|
| Target Name | NSD2 |
| Gene Abbr. | NSD2 |
| Gene ID | 7468 |
| Full Name | nuclear receptor binding SET domain protein 2 |
| Alias | KMT3F, KMT3G, MMSET, REIIBP, TRX5 |
| Species | Human |
| Genomic Locus | 4p16.3 |
| Introduction | This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008]. |
| Product Details | |
|---|---|
| Cell Line Model | KMS-11 |
| Genotype | WHSC1 (+/-) |
| Description | WHSC1 (+/-) |
| Parental ATCC ID | Japanese Collection of Research Bioresources (JCRB): JCRB1179 |
| STR Profile | Amelogenin: X; CSF1PO: 13; D13S317: 12; D16S539: 9, 13; D5S818: 10, 12; D7S820: 11, 12; THO1: 6,9; TPOX: 12; vWA: 17,18; |
| Disease | Myeloma |
| Tissue | Pleural effusion |
| Gender | Female |
| Key Endogenous Mutations | FGFR3 |
| CVT Selection Condition | No antibiotic resistance |
| Cell Number | 1x10^6 |
| Handling Specifications | |
|---|---|
| Revival | Cells are cultured at 37°C in a humidified atmosphere with 5% CO2. Cells should be passaged every 3-5 days. Split at 70-80% confluency, approximately 1:4-1:6 |
| Culture Medium | RPMI 1640 including 2 mM L-glutamine and 25 mM sodium bicarbonate, supplemented with 10% FBS. |
| Growth Properties | Cells are cultured at 37°C in a humidified atmosphere with 5% CO2. Cells should be passaged every 3-5 days. Split at 70-80% confluency, approximately 1:4-1:6 |
| Freeze Medium | Complete growth media 40% + USDA approved FBS 50% + DMSO 10% |
| Biosafety Level | BSL-1 |
| Disclaimer | This product is classified under IATA regulations as a GMMO (genetically modified micro-organism) and will ship as UN3245. If applicable, ensure facility meets all requirements per local and country regulations. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.