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Venetoclax (ABT-199)
SPC-02332
CAS No. 1257044-40-8
| Size | Price |
| 10 mM (1 mL in DMSO) | Online Inquiry |
| 5 mg | Online Inquiry |
| 50 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
Bcl-2 inhibitor ; Autophagy activator
| Description |
|---|
| Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 1257044-40-8 |
| Description | Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Venetoclax is reported to induce cell growth suppression, apoptosis, cell cycle arrest, and autophagy in triple negative breast cancer MDA-MB-231 cells. Phase 3. |
| Formula | C45H50ClN7O7S |
| Molecular Weight | 868.44 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | GDC-0199 |
| SMILES | CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C |
| Solubility | DMSO |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.