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VEGF Receptor 3 Antibody
SPA-11734
| Size | Price |
| 0.05 mg | Online Inquiry |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | VEGF Receptor |
| Gene Abbr. | FLT4 |
| Gene ID | 2324 |
| Full Name | fms related receptor tyrosine kinase 4 |
| Alias | CHTD7, FLT-4, FLT41, LMPH1A, LMPHM1 |
| Introduction | Vascular endothelial growth factor receptor 3 (VEGFR3) is a 195 kDa membrane receptor tyrosine kinase. VEGF receptors are characterized by the presence of seven extracellular immunoglobulin (Ig)-like domains followed by a membrane-spanning domain and a conserved intracellular tyrosine kinase domain. VEGF receptor 3 expression is largely restricted to adult lymphatic endothelium and is thought to control lymphangiogenesis. Binding of VEGF-C/VEGF-D to VEGFR3 results in transphosphorylation of tyrosine residues in its intracellular domain, recruitment of signaling molecules and activation of ERK1/2 and Akt signaling cascades. |
| Product Details | |
|---|---|
| Host | Rat |
| Clonality | Monoclonal |
| Clone No. | RM0003-5F63 |
| Isotype | IgG2 |
| Immunogen | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse VEGFR3 extracellular domain. |
| Usage | |
|---|---|
| Application | WB, IF, IHC |
| Dilutions | Western Blot (1:400-1:800); Immunohistochemistry (1:100-1:500) |
| MW(KDa) | 175, 195 |
| Reactivity | Mouse |
| Specificity | No cross reactivity to mouse VEGFR1 and VEGFR2. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from 0.2 µm filtered PBS. |
| Preservative | No Preservative |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.