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Vandetanib (ZD6474)
SPC-02322
CAS No. 443913-73-3
| Size | Price |
| 10 mM (1 mL in DMSO) | Online Inquiry |
| 10 mg | Online Inquiry |
| 25 mg | Online Inquiry |
| 50 mg | Online Inquiry |
| 100 mg | Online Inquiry |
| 500 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
VEGFR inhibitor ; EGFR inhibitor ; Apoptosis related activator ; Autophagy activator ; ROS activator
| Description |
|---|
| Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS). |
| Product Details | |
|---|---|
| CAS No. | CAS No. 443913-73-3 |
| Description | Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS). |
| Formula | C22H24BrFN4O2 |
| Molecular Weight | 475.35 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | N/A |
| SMILES | CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC |
| Solubility | DMSO |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
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