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TWEAK/TNFSF12 Antibody
SPA-11529
| Size | Price |
| 0.1 mg | Online Inquiry |
| 0.025 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | TWEAK |
| Gene Abbr. | TNFSF12 |
| Gene ID | 8742 |
| Full Name | TNF superfamily member 12 |
| Alias | APO3L, DR3LG, TNLG4A, TWEAK |
| Introduction | TWEAK (TNFSF12/Apo-3L) is a member of the TNF superfamily of cytokines that are typically involved in immune regulation, inflammation, and apoptosis. TWEAK mRNA is expressed in a variety of tissues and cell lines, with higher levels observed in the heart, brain, skeletal muscle and within the immune system. Like other family members TWEAK is a type II transmembrane protein that can also be proteolytically processed to form a soluble cytokine. Soluble TWEAK is a weak inducer of apoptosis in some cell lines. The receptor for TWEAK, known as TWEAKR or fibroblast growth factor inducible 14 (Fn14), is a relatively small member of the TNF receptor family. TWEAK signaling has been associated with apoptosis, proliferation, migration, angiogenesis, and inflammation. Recent studies have suggested some therapeutic potential of TWEAK and its receptor signaling in regards to autoimmunity, cancer, and vascular injury. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Antibody was raised against recombinant human TWEAK/TNFSF12 protein. |
| Usage | |
|---|---|
| Application | WB, ELISA, IHC, IF |
| Dilutions | Western Blot (0.5-4 µg/mL); ELISA (1:100-1:2000); Immunohistochemistry (5-10 µg/mL); Immunofluorescence (20 µg/mL) |
| Reactivity | Human, Mouse, Rat |
| Specificity | Human TWEAK/TNFSF12 has 2 isoforms, including isoform 1 (249aa, 27kD) and isoform 2 (330aa, 36kD). Mouse TWEAK/TNFSF12 has one isoform (249aa, 27kD) and Rat TWEAK/TNFSF12 also has one isoform (249aa, 27kD). |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.