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TROY/TNFRSF19 Antibody
SPA-10887
| Size | Price |
| 0.025 mg | Online Inquiry |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | TNF receptor |
| Gene Abbr. | TNFRSF19 |
| Gene ID | 55504 |
| Full Name | TNF receptor superfamily member 19 |
| Alias | TAJ, TAJ-alpha, TRADE, TROY |
| Introduction | TROY, also known as TAJ (Toxicity and JNK inducer), and TRADE, is a type I tramsmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF19. Two alternatively spliced transcript variants for human TROY, encoding a 423 amino acid (aa) residues isoforms 1 precursor and a 417 aa isoform 2 precursor have been cloned. The two isoforms differ in their cytoplasmic C-terminal residues. In mouse, a soluble TROY isoform and a transmembrane isoform with a short cytoplasmic tail have also been described. Human TROY isoform 1 cDNA encodes a precursor protein with a putative 23 aa signal peptide, a 147 aa extracellular domain containing two TNF receptor cysteine-rich domains, a 23 aa transmembrane domain and a 230 aa cytoplasmic region containing no death domain. The extracellular domain of human TROY shares 92% aa sequence identity with that of the mouse TROY. In their cytoplasmic domains, the two proteins also share 57% sequence homology. Among TNFRSF members, the extracellular region of TROY is most closely related to EDAR, exhibiting 33% homology. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human TROY/TNFRSF19. Glu30-Leu170. Accession # AAF71828. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (0.1 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human TROY/TNFRSF19 in direct ELISAs and Western Blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse (rm) TROY is observed and less than 1% cross-reactivity with recombinant human (rh) 4-1BB, rhBAFF R, rhCD27, rhCD30, rhCD40, rhDR3, rhDR6, rhEDAR, rhFas, rhGITR, rhHVEM, rhNGF R, rhOPG, rhRANK, rhTNF RI, and rhTNF RII is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.