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Triptolide (PG490)
SPC-02273
CAS No. 38748-32-2
| Size | Price |
| 1 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
ADC Cytotoxin chemical ; NF-κB inhibitor ; Mdm2 inhibitor ; Apoptosis related activator ; HSP (HSP90) inhibitor
| Description |
|---|
| Triptolide (PG490, NSC 163062) is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 38748-32-2 |
| Description | Triptolide (PG490, NSC 163062) is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway. |
| Formula | C20H24O6 |
| Molecular Weight | 360.4 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | NSC 163062 |
| SMILES | CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.