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TRAILR4/TNFRSF10D/DcR2 Antibody
SPA-10812
| Size | Price |
| 0.1 mg | Online Inquiry |
| 0.025 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | TNF receptor |
| Gene Abbr. | TNFRSF10D |
| Gene ID | 8793 |
| Full Name | TNF receptor superfamily member 10d |
| Alias | CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD |
| Introduction | Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | A 15 amino acid peptide near the center of human DcR2. The immunogen is located within amino acids 230 - 280 of DcR2. Amino Acid Squence: GGPERVHRVLFRRRS. |
| Usage | |
|---|---|
| Application | WB, ELISA, FC, IF, IHC |
| Dilutions | Western Blot (1 µg/mL); ELISA (1:100-1:2000); Immunofluorescence (10-20 µg/mL); Immunohistochemistry (2.5 µg/mL) |
| Reactivity | Human, Mouse, Rat |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.