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TRAILR3/TNFRSF10C/DcR1 Antibody
SPA-10809
| Size | Price |
| 0.1 mg | Online Inquiry |
| 0.025 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | TNF receptor |
| Gene Abbr. | TNFRSF10C |
| Gene ID | 8794 |
| Full Name | TNF receptor superfamily member 10c |
| Alias | CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3 |
| Introduction | Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | A synthetic peptide corresponding to amino acids 155-168 ([BLAST]CSSSVSNPRNWLFL[/BLAST]) of mouse DcTrailR1; GenBank no: NP_077252.2. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (1-3 µg/mL) |
| Reactivity | Human, Mouse |
| Specificity | In mouse spleen, a 20 kDa band is observed. The amino acid sequence used is 92% homologous in DcTrailR2. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS containing 0.2% gelatin. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.