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TRAIL Antibody
SPA-11275
| Size | Price |
| 0.025 mg | Online Inquiry |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | TRAIL |
| Gene Abbr. | TNFSF10 |
| Gene ID | 8743 |
| Full Name | TNF superfamily member 10 |
| Alias | APO2L, Apo-2L, CD253, TL2, TNLG6A |
| Introduction | Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also referred to as Apo2 ligand, first identified based on its sequence homology to TNF and Fas/Apo ligand is a member of the TNF family of cytokines and either exists as a type II membrane or soluble protein. TRAIL induces apoptosis in a variety of transformed cell lines and plays a role in anti-tumor and anti-viral immune surveillance. TRAIL signals via binding with death receptors DR4 (TRAIL-R1) and DR5 (TRAIL-R2) which can trigger apoptosis as well as NF-κB activation. Death domains on these receptors leads to the recruitment of a death-induced signaling complex (DISC) leading to caspase-8 and subsequent caspase-3 activation. In addition, TRAIL binds with decoy receptors DcR1 (TRAIL-R3) and DcR2 (TRAIL-R4, TRUNDD) which lack the functional cytoplasmic death domain antagonizing TRAIL-induced apoptosis. Osteoprotegerin (OPG) has also been identified as receptor capable of inhibiting TRAIL-induced apoptosis. The selectivity of soluble TRAIL at triggering apoptosis in transformed cells as compared to normal cells has led to its investigation as a potential cancer therapeutic. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 75411.11 |
| Isotype | IgG1 |
| Immunogen | Recombinant full length protein (Human). |
| Usage | |
|---|---|
| Application | WB, ELISA |
| Dilutions | Western Blot (1-2 µg/mL); ELISA (0.5-1 µg/mL) |
| MW(KDa) | 28-30 |
| Reactivity | Human |
| Specificity | In immunoblots, this demonstrates approximately 5% cross-reactivity with recombinant human Trance and recombinant human TNF alpha. |
| Storage & Handling | |
|---|---|
| Storage Buffer | 10 mM Sodium Phosphate (pH 7.6), 0.25 M NaCl and 15 mg/mL BSA. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.