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TRAF2 Antibody
SPA-11221
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | TRAF2 |
| Gene Abbr. | TRAF2 |
| Gene ID | 7186 |
| Full Name | TNF receptor associated factor 2 |
| Alias | MGC:45012, RNF117, TRAP, TRAP3 |
| Introduction | TRAFs (TNF receptor-associated factors) are a family of multifunctional adaptor proteins that bind to surface receptors and recruit additional proteins to form multiprotein signaling complexes capable of promoting cellular responses. Members of the TRAF family share a common carboxy-terminal "TRAF domain", which mediates interactions with associated proteins; many also contain amino-terminal Zinc/RING finger motifs. The first TRAFs identified, TRAF1 and TRAF2, were found by virtue of their interactions with the cytoplasmic domain of TNF-receptor 2 (TNFRII). The six known TRAFs (TRAF1-6) act as adaptor proteins for a wide range of cell surface receptors and participate in the regulation of cell survival, proliferation, differentiation, and stress responses.TRAF2 is phosphorylated at Ser11 by IKK-ε, promoting K63-linked ubiquitination, NF-κB activation, and cellular transformation. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 324522 |
| Isotype | IgG2A |
| Immunogen | E. coli-derived recombinant human TRAF-2. Met1-Leu501. Q12933. |
| Usage | |
|---|---|
| Application | WB, IF |
| Dilutions | Western Blot (0.25 µg/mL); Immunofluorescence (3-25 µg/mL) |
| MW(KDa) | 53 |
| Reactivity | Human, Mouse, Rat |
| Validation | Knockout Validated. |
| Specificity | Detects human, mouse, and rat TRAF-2 in direct ELISAs and Western Blots. In direct ELISAs and Western Blots, no cross-reactivity with recombinant human TRAF-1, -3, -4, -5, or -6 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.