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Total SQSTM1/p62 Sandwich ELISA Kit
SPK-00897
Size | Price |
1 X 96T | Online Inquiry |
5 X 96T | Online Inquiry |
10 X 96T | Online Inquiry |
More Options | Online Inquiry |
Target Information | |
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Target Name | p62/SQSTM1 |
Gene Abbr. | SQSTM1 |
Gene ID | 8878 |
Full Name | sequestosome 1 |
Alias | A170, DMRV, FTDALS3, NADGP, OSIL |
Introduction | SQSTM1 (Sequestrome-1), also called p62, is a widely expressed, stress-inducible, multifunctional 62 kDa intracellular protein. The 440 amino acid (aa) human SQSTM1 contains multiple adaptor domains that allow interaction with proteins in NGF/NFkB and other signaling pathways (notably TRAF6, atypical protein kinase C family and Src family), polyubiquitin, proteasome subunits and many others. It contains numerous regulatory phosphorylation sites and a dimerization site. SQSTM1 shuttles ubiquitinylated proteins to the proteasome and is important in autophagy and apoptosis. Its dysregulation is associated with Paget’s disease of bone, Parkinson’s and Alzheimer’s diseases, and cancers. Within aa 344-440, which includes the ubiquitin-binding domain, human SQSTM1 shares 100% aa sequence identity with mouse and rat SQSTM1. |
Product Details | |
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Measurement | Sandwich |
Usage | |
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Application | ELISA |
Reactivity | |
Sensitivity | This kit detects endogenous levels of SQSTM1/p62 protein in human cells. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.