Total SQSTM1/p62 Sandwich ELISA Kit - CD BioSciences

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Total SQSTM1/p62 Sandwich ELISA Kit

Total SQSTM1/p62 Sandwich ELISA Kit

SPK-00897

Size Price
1 X 96T Online Inquiry
5 X 96T Online Inquiry
10 X 96T Online Inquiry
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Target Information
Target Name p62/SQSTM1
Gene Abbr. SQSTM1
Gene ID 8878
Full Name sequestosome 1
Alias A170, DMRV, FTDALS3, NADGP, OSIL
Introduction SQSTM1 (Sequestrome-1), also called p62, is a widely expressed, stress-inducible, multifunctional 62 kDa intracellular protein. The 440 amino acid (aa) human SQSTM1 contains multiple adaptor domains that allow interaction with proteins in NGF/NFkB and other signaling pathways (notably TRAF6, atypical protein kinase C family and Src family), polyubiquitin, proteasome subunits and many others. It contains numerous regulatory phosphorylation sites and a dimerization site. SQSTM1 shuttles ubiquitinylated proteins to the proteasome and is important in autophagy and apoptosis. Its dysregulation is associated with Paget’s disease of bone, Parkinson’s and Alzheimer’s diseases, and cancers. Within aa 344-440, which includes the ubiquitin-binding domain, human SQSTM1 shares 100% aa sequence identity with mouse and rat SQSTM1.
Product Details
Measurement Sandwich
Usage
Application ELISA
Reactivity
Sensitivity This kit detects endogenous levels of SQSTM1/p62 protein in human cells.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.