Toll-like Receptor 6/TLR6 Antibody - CD BioSciences

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Toll-like Receptor 6/TLR6 Antibody

Toll-like Receptor 6/TLR6 Antibody

SPA-11134

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Target Information
Target Name Toll-like Receptor
Gene Abbr. TLR6
Gene ID 10333
Full Name toll like receptor 6
Alias CD286
Introduction Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the Toll/Interleukin-1 receptor (TIR) domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains, including myeloid differentiation factor 88 (MyD88), MyD88-adaptor-like/TIR-associated protein (MAL/TIRAP), Toll-receptor-associated activator of interferon (TRIF), and Toll-receptor-associated molecule (TRAM). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK.Activation of IKK leads to the degradation of IκB, which normally maintains NF-κB in an inactive state by sequestering it in the cytoplasm.Toll-like receptor 6 (TLR6) heterodimerizes with TLR2 and is expressed on the cell surface where it recognizes fungal zymosan and bacterial lipoproteins. In addition, a heterodimer of TLR4 and TLR6 was recently shown to assemble downstream of CD36 signaling and contribute to sterile inflammation in response to CD36 ligands, including low-density lipoprotein and β-amyloid.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. D1Z8B
Immunogen Synthetic peptides corresponding to residues surrounding Pro47 of human and mouse TLR6 protein.
Source/Purification Antibody is produced by immunizing animals with synthetic peptides corresponding to residues surrounding Pro47 of human and mouse TLR6 protein.
Usage
Application WB, IP
Dilutions Western Blot (1:1000); Immunoprecipitation (1:50)
MW(KDa) 90-110
Reactivity Human, Mouse
Sensitivity Endogenous
Specificity It recognizes endogenous levels of total TLR6 protein. This antibody cross-reacts with a 72 kDa protein of unknown origin. This antibody is not approved for IP in mouse samples.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.