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TNFRSF10D cDNA ORF Clone, Human, In cloning vector
SPD-14857
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| Full length Clone DNA of Human tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain (TNFRSF10D). |
| Target Information | |
|---|---|
| Species | Human |
| Target Name | TNF Receptor |
| Gene Abbr. | TNFRSF10D |
| Gene ID | 8793 |
| Full Name | TNF receptor superfamily member 10d |
| Alias | CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD |
| Introduction | Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis. |
| Product Details | |
|---|---|
| Description | Full length Clone DNA of Human tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain (TNFRSF10D). |
| NCBI Ref Seq | NM_003840.3 |
| RefSeq ORF Size | 1161 bp |
| Sequence Information | Identical with the Gene Bank Ref. ID sequence except for two adjacent point mutations 1160,1161 GA/CT which causes the Stop codon conversion into Ser and a point mutation 929T/C resulting in the amino acid Leu substitution by Ser. |
| Vector | pMD18-T Simple Vector |
| Quality Control | The plasmid is confirmed by full-length sequencing. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
| Usage | |
|---|---|
| Sequencing Primers | M13-47 and RV-M |
| Antibiotic in E.coli | Ampicillin |
| Shipping | Each tube contains lyophilized plasmid. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.