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TESK1 Antibody
SPA-10668
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | TESK1 |
| Gene Abbr. | TESK1 |
| Gene ID | 7016 |
| Full Name | testis associated actin remodelling kinase 1 |
| Introduction | Testis-specific kinase 1 (TESK1) is a LIMK-related protein kinase originally identified to be expressed highly in testes and subsequently shown to be expressed in a wide variety of tissues and cell types. TESK1 phosphorylates the actin severing protein cofilin at Ser3, inactivating cofilin and thus regulating the organization of the actin cytoskeleton. Integrin signaling activates TESK1 activity and leads to stress fiber formation and cell spreading. TESK1 is involved in regulation of ERK signaling through its interaction with Spry2 and regulation of cell spreading through its interaction with the focal adhesion protein actopaxin/α-parvin. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | D49D4 |
| Immunogen | Synthetic peptide corresponding to carboxy terminal residues of human TESK1 protein. |
| Source/Purification | Antibody is produced by immunizing animals with a synthetic peptide corresponding to carboxy terminal residues of human TESK1 protein. |
| Usage | |
|---|---|
| Application | WB, IP |
| Dilutions | Western Blot (1:1000); Immunoprecipitation (1:200) |
| MW(KDa) | 68 |
| Reactivity | Human |
| Sensitivity | Endogenous |
| Specificity | It detects endogenous levels of total TESK1 protein. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. |
| Preservative | Less than 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.