Human Lung Tissue Cell MRC5 Transfection Kit

Modes of administration

Reagent exhibits at least 80% transfection efficiency of siRNA delivery. Transfection efficiency was determined by qRT-PCR.

Description

MRC-5, or Medical Research Council cell strain 5, is a cell line that originated from the lung tissue of a 14-week-old male fetus. These cells have become a staple in biomedical research and vaccine production. MRC-5 cells are diploid fibroblast cells that exhibit the ability to grow as adherent monolayers in vitro. They have a normal karyotype and can secrete extracellular matrix components, such as collagen and fibronectin, which are typical characteristics of fibroblast cells.

MRC-5 cells have been used in numerous studies of viral infections, particularly in relation to human cytomegalovirus (HCMV). These cells have shown to be highly receptive to HCMV infection, and thus they are frequently used as a substrate for the growth of the virus in vitro. Additionally, MRC-5 cells have been used to investigate the bewildering mechanisms that underlie virus-induced cell transformation, as well as to screen for potential antiviral agents.

Moreover, MRC-5 cells have played a substantial role in the production of several vaccines, including those for rubella, varicella, and hepatitis A. These cells are significantly utilized in vaccine production due to their ability to support the replication of various types of viruses.

For scientists and researchers seeking efficient and reliable genetic modification of MRC-5 cells, CD BioSciences offers an advanced and bursty nanoparticle-based liposome formulation MRC-5 transfection reagent kit for diploid fibroblast cells. The kit has demonstrated high transfection efficiency, as detected by qRT-PCR, making it a striking choice for those in search of the best tools for their research.