Polysaccharides are a kind of complex molecular structure and larger carbohydrates formed by the polymerization of more than 10 monosaccharide molecules through glycosidic bonds. Human research on polysaccharides is synchronized with proteins and nucleic acids. However, due to the complex structure of polysaccharides and other reasons, its research lags far behind proteins and nucleic acids. The study of polysaccharides as drugs began in the 1950s, and up to now, hundreds of polysaccharides have been found to be biologically active. Similar to proteins, the structure of polysaccharides can also be divided into primary structure and advanced structure. The primary structure includes the composition of sugar groups, the arrangement order of sugar groups, the connection mode of adjacent sugar groups, whether the sugar chain is branched, the position and length of the branch, and the situation of derivatives, etc.; the advanced structure refers to the complex spatial structure formed by the combination of side chains through non-covalent interactions on the basis of the primary structure. Both primary and high-level structures determine its biological activity.

Figure 1. The design strategies of polysaccharide-based drug delivery systems.(Sun Y, et al.; 2020)

Polysaccharides are macromolecular compounds with different molecular chain lengths. The relative molecular mass of polysaccharides has a certain relationship with its properties. Generally speaking, the larger the relative molecular weight of polysaccharides, the larger the hydrodynamic volume, which is more unfavorable for them to cross multiple cell membrane barriers by passive diffusion and enter the organism to exert biological activity; lowering the relative molecular weight can sometimes improve the solubility of polysaccharides, thereby Enhance its activity, but if the relative molecular weight is too low, it will not be able to form an active polymeric structure, resulting in the loss of polysaccharide activity. In order to overcome the shortcomings, CD BioSciences has developed an in vivo polysaccharides delivery system using nanoparticles as carriers. The polysaccharides encapsulated by our carrier has good stability, long half-life in vivo, obvious therapeutic effect, and low toxic and side effects of the drug.

CD BioSciences provides customized delivery strategies, through the precise design and modification of delivery vehicles, as well as advanced technology platforms, can help you solve:

• There is no suitable method for polysaccharides delivery to specific tissues and organs in the body;
• Polysaccharidess cannot easily cross cell membranes due to their size and surface chemistry
• Low bioavailability
• Low payload of in vivo delivery systems
• Polysaccharidess are diluted and degraded during in vivo delivery without protection
• Poor stability of polysaccharides in vivo
• The release of polysaccharides in the body is uncontrolled
• Etc…

Key Features

Polysaccharide Nanoparticles

• PLGA
• Chitosan

Polysaccharide Liposome

• Long-circulating liposomes
• Targeting liposomes
• pH sensitive liposomes
• Immunoliposomes
• Magnetic liposomes

Polysaccharide Microspheres and Microcapsules

Our Advantage:

• CD BioSciences can provide professional polysaccharides in vivo delivery system to achieve efficient in vivo delivery;
• Our delivery system can add modified ligands to achieve targeting;
• The in vivo polysaccharides delivery system has low toxicity to the body and is safe to use
• In vivo polysaccharides delivery system Carriers protect polysaccharidess from dilution and degradation during in vivo delivery
• The delivery system can achieve timing, location, fixed rate and targeted release in vivo, so that experimental animals have a long-lasting effect after a single injection
• The system load is high, and the delivery requirements of different doses can be fulfilled
• Professional design and service team to provide you with reliable service and technical support feedback technical report in time

CD BioSciences is focused on developing in vivo delivery systems using our core technologies. With our high-quality products and services, your delivery effect will be greatly improved. If you can't find the perfect in vivo delivery system, you can contact us. We can provide one-to-one personal customization services.

References

1. SARANGI I, et al.; Anti-tumor and immunomodulating effects of Pleurotus ostreatus myceliaderived proteoglycans. Int Immunopharmacol. 2006, 6(8): 1287-1297.
2. SRIAMORNASK P, et al.; Calcium pectinate gel beads for controlled release drug delivery: Preparation and in vitro release studies. Int J Pharm. 1998, 160(2): 207-212.
3. KLUGMAN K P, et al.; Immunogenicity, efficacy and serological correlate of protection of Salmanella typhi Vi vaccine three years after immunization. Vaccine. 1996, 14(5): 435-438.
4. JESUS M, et al.; Glyconanoparticles: Types, synthesis and applications in glycoscience, biomedicine and material science. Biochim Biophys Acta. 2006, 1760(4): 636-651.
5. Sun Y, et al.; Versatile Types of Polysaccharide-Based Drug Delivery Systems: From Strategic Design to Cancer Therapy. Int J Mol Sci. 2020, 21(23):9159.

* For research use only. Not for use in clinical diagnosis or treatment of humans or animals.