Human Coronary Arteries of Endothelial Cells HCAEC Transfection Kit

Modes of administration

Reagent exhibits at least 80% transfection efficiency of siRNA delivery. Transfection efficiency was determined by qRT-PCR.

Description

The HCAEC cell line is derived from the endothelial cells that line the coronary arteries of the human heart. These cells are frequently employed as a model system for studying the biology and pathology of coronary arteries, as well as to investigate the mechanisms of cardiovascular diseases. HCAECs express various markers characteristic of endothelial cells, including von Willebrand factor, and form capillary-like structures when grown on extracellular matrix proteins like Matrigel. They also exhibit many functions typical of endothelial cells, such as regulating vascular tone, angiogenesis, and leukocyte adhesion. HCAECs are widely used in experiments to explore the genetic and molecular mechanisms behind endothelial cell function and dysfunction in cardiovascular diseases, and to assess the safety and efficacy of potential therapeutic agents for cardiovascular conditions. CD BioSciences produces nanoparticle-based transfection reagent kits that are specifically designed for coronary artery endothelial cells, which have demonstrated reproducible and high-efficiency transfection outcomes.