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Tau Antibody
SPA-10634
| Size | Price |
| 0.025 mL | Online Inquiry |
| 0.1 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Tau |
| Gene Abbr. | MAPT |
| Gene ID | 4137 |
| Full Name | microtubule associated protein tau |
| Alias | DDPAC, FTDP-17, MAPTL, MSTD, MTBT1 |
| Introduction | Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | Tau46 |
| Isotype | IgG1 |
| Immunogen | BALB/C mice were injected with purified bovine Tau. |
| Usage | |
|---|---|
| Application | IHC |
| Reactivity | Human |
| Specificity | This antibody is specific to 45-60 kD proteins identified as tau proteins. This antibody does not cross react with tubulin or other microtubule associated proteins. This antibody recognizes a phosphorylation-independent epitope in amino acids 404-441 (human). Tau antibody stains human neurofibrillary tangles, neutrophil threads and neurotic plaques associated with Alzheimer's disease. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS with BSA. |
| Preservative | Sodium Azide |
| Storage Temp. | Store at 4 °C. |
| Handling | Do not freeze. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.