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Tau Antibody
SPA-10623
| Size | Price |
| 0.025 mL | Online Inquiry |
| 0.1 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Tau |
| Gene Abbr. | MAPT |
| Gene ID | 4137 |
| Full Name | microtubule associated protein tau |
| Alias | DDPAC, FTDP-17, MAPTL, MSTD, MTBT1 |
| Introduction | Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 5B10 |
| Isotype | IgG1 |
| Immunogen | Recombinant full length 441 amino acid version of the shortest human tau isoform. Epitope located in the peptide HVPGGGNKKIETHKLTFREN, amino acids 362-381. [UniProt# P10636]. |
| Usage | |
|---|---|
| Application | WB, IF, IHC |
| Dilutions | Western Blot (1:10000); Immunofluorescence (1:1000); Immunohistochemistry (1:1000) |
| Reactivity | Human, Mouse, Rat |
| Specificity | This antibody is expected to bind to all Tau isoforms. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS, 50% glycerol (1:1). |
| Preservative | 5 mM Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.