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TAB1 Antibody
SPA-10530
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | TAB1 |
| Gene Abbr. | TAB1 |
| Gene ID | 10454 |
| Full Name | TGF-beta activated kinase 1 (MAP3K7) binding protein 1 |
| Alias | 3'-Tab1, MAP3K7IP1 |
| Introduction | TAK1 is a mitogen-activated protein kinase kinase kinase activated by TGF-β and various pro-inflammatory signals. In vivo, TAK1 activation requires its association with TAK1 binding protein 1 (TAB1), which triggers TAK1 autophosphorylation at Thr184 and Thr187. The TAB2 adaptor protein links TAK1 with TRAF6 to mediate TAK1 activation following IL-1 stimulation. Once activated, TAK1 phosphorylates the MAPK kinases MKK4 and MKK3/6, which activate JNK and p38 MAPK, respectively. TAK1 and TRAF6 also activate the NF-κB pathway by phosphorylating the NF-κB inducing kinase (NIK) to trigger subsequent activation of IKK. In addition to TAK1, TAB1 interacts with and activates p38α MAPK. Targeted disruption of the TAB1 gene in mice causes a drastic reduction in TAK1 activity and leads to embryonic lethality. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | The immunogen recognized by this antibody maps to a region between residue 435 and 485 of human TAK1-binding protein 1 using the numbering given in entry NP_006107.1 (GeneID 10454). |
| Usage | |
|---|---|
| Application | WB, IP |
| Dilutions | Western Blot (1:2000-1:10000); Immunoprecipitation (2-5 μg/mg lysate) |
| MW(KDa) | 60 |
| Reactivity | Human, Mouse |
| Storage & Handling | |
|---|---|
| Storage Buffer | TBS and 0.1% BSA. |
| Preservative | 0.09% Sodium Azide |
| Storage Temp. | Store at 4 °C. |
| Handling | Do not freeze. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.