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Stathmin-2/STMN2 Antibody
SPA-10406
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Stathmin |
| Gene Abbr. | STMN2 |
| Gene ID | 11075 |
| Full Name | stathmin 2 |
| Alias | SCG10, SCGN10 |
| Introduction | Stathmin is a ubiquitously expressed microtubule destabilizing phosphoprotein that is upregulated in a number of cancers. The amino terminus of the protein contains multiple phosphorylation sites and is involved in the promotion of tubulin filament depolymerization. Phosphorylation at these sites inactivates the protein and stabilizes microtubules. Ser16 phosphorylation by CaM kinases II and IV increases during G2/M-phase and is involved in mitotic spindle regulation. Ser38 is a target for cdc2 kinase and TNF-induced cell death gives rise to reactive oxygen intermediates leading to hyperphosphorylation of stathmin. EGF receptor activation of Rac and cdc42 also increases phosphorylation of stathmin on Ser16 and Ser38. Other closely related family members are neuronally expressed and include SCG10, SCLIP, RB3 and its splice variants RB3' and RB3''. Stathmin and SCG10 have been shown to play roles in neuronal-like development in PC-12 cells. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 684433 |
| Isotype | IgG2B |
| Immunogen | E. coli-derived recombinant human Stathmin-2/STMN2. Tyr26-Gly179. Q93045. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (0.05 µg/mL); Immunohistochemistry (8-25 µg/mL) |
| Reactivity | Human, Mouse |
| Specificity | Detects human Stathmin-2/STMN2 in direct ELISAs and Western Blots. In Western Blots, no cross-reactivity with recombinant human Stathmin-1, -3, or -4 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.