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Sorafenib Tosylate
SPC-02061
CAS No. 475207-59-1
| Size | Price |
| 10 mM (1 mL in DMSO) | Online Inquiry |
| 10 mg | Online Inquiry |
| 100 mg | Online Inquiry |
| 300 mg | Online Inquiry |
| 500 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
Raf inhibitor ; PDGFR inhibitor ; VEGFR inhibitor ; FLT3 inhibitor ; c-Kit inhibitor ; FGFR inhibitor ; Ferroptosis activator ; Autophagy activator ; Apoptosis related activator
| Description |
|---|
| Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 475207-59-1 |
| Description | Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity. |
| Formula | C21H16ClF3N4O3.C7H8O3S |
| Molecular Weight | 637.03 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | Bay 43-9006 |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F |
| Solubility | DMSO |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
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