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Sorafenib
SPC-02060
CAS No. 284461-73-0
| Size | Price |
| 20 mg | Online Inquiry |
| 200 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
Raf inhibitor ; VEGFR inhibitor ; PDGFR inhibitor ; FLT3 inhibitor ; Autophagy activator ; Apoptosis related activator ; Ferroptosis activator
| Description |
|---|
| Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 284461-73-0 |
| Description | Sorafenib (BAY 43-9006) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity. |
| Formula | C21H16ClF3N4O3 |
| Molecular Weight | 464.82 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | BAY 43-9006 |
| SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.