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Smac/Diablo Antibody
SPA-10058
| Size | Price |
| 0.05 mL | Online Inquiry |
| 0.2 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Smac/Diablo |
| Gene Abbr. | DIABLO |
| Gene ID | 56616 |
| Full Name | diablo IAP-binding mitochondrial protein |
| Alias | DFNA64, SMAC |
| Introduction | Smac/Diablo is a 21 kDa mammalian mitochondrial protein that functions as a regulatory component during apoptosis. Upon mitochondrial stress, Smac/Diablo is released from mitochondria and competes with caspases for binding of IAPs (inhibitor of apoptosis proteins). The interaction of Smac/Diablo with IAPs relieves the inhibitory effect of the IAPs on caspases. This interaction involves mainly the amino-terminal residues of Smac/Diablo with the BIR3 region of XIAP, supplemented with several other hydrophobic interactions between the helical structures of Smac/Diablo and other areas of BIR3. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | E. coli-derived recombinant human SMAC/Diablo. Ala56-Asp239. Q9NR28. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (0.5 µg/mL); Immunohistochemistry (5-15 µg/mL) |
| MW(KDa) | 21 |
| Reactivity | Human |
| Specificity | Detects human, mouse, and rat SMAC/Diablo in direct ELISAs and Western Blots. No cross-reactivity with recombinant human NME3 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.