Online Inquiry
SLIT2 Antibody
SPA-10037
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | SLIT2 |
| Gene Abbr. | SLIT2 |
| Gene ID | 9353 |
| Full Name | slit guidance ligand 2 |
| Alias | SLIL3, Slit-2 |
| Introduction | SLIT2 is an extracellular matrix-associated SLIT family member that functions as a ligand for roundabout (ROBO) family receptors. Activation of ROBO receptors by SLIT2 regulates various biological processes, including promoting cellular senescence via WNT inhibition suppressing migration by enhanced β-catenin/E-cadherin association, regulating actin polymerization, and suppressing cell proliferation induced by SDF1 and MCP1. In development, the SLIT-ROBO pathways play important roles in neuronal axon guidance, angiogenesis, and both kidney and mammary gland organogenesis. SLIT2 expression has been reported to suppress cancer cell growth, invasion, and metastasis, suggesting that modulation of SLIT2-ROBO signaling may have therapeutic potential in cancer biology. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | E8W7Y |
| Immunogen | Synthetic peptide corresponding to residues surrounding Gln1463 of human SLIT2 protein. |
| Source/Purification | Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln1463 of human SLIT2 protein. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (1:1000) |
| MW(KDa) | 200 |
| Reactivity | Human, Mouse, Rat |
| Sensitivity | Endogenous |
| Specificity | It recognizes endogenous levels of total SLIT2 protein. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. |
| Preservative | Less than 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.