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Selitrectinib (LOXO-195)
SPC-01997
CAS No. 2097002-61-2
| Size | Price |
| 5 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
Trk receptor inhibitor
| Description |
|---|
| Selitrectinib (LOXO-195, BAY 2731954) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 2097002-61-2 |
| Description | Selitrectinib (LOXO-195, BAY 2731954) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested. |
| Formula | C20H21FN6O |
| Molecular Weight | 380.42 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | BAY 2731954 |
| SMILES | CC1CCC2=C(C=C(C=N2)F)C3CCCN3C4=NC5=C(C=NN5C=C4)C(=O)N1 |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.