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SEK1/MKK4 Antibody
SPA-09883
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | SEK1/MKK4 |
| Gene Abbr. | MAP2K4 |
| Gene ID | 6416 |
| Full Name | mitogen-activated protein kinase kinase 4 |
| Alias | JNKK, JNKK1, MAPKK4, MEK4, MKK4 |
| Introduction | SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines. Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop. Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | OTI8A8 |
| Isotype | IgG2B |
| Immunogen | Full-length protein expressed in 293T cell transfected with human MAP2K4 expression vector. |
| Usage | |
|---|---|
| Application | WB, FC, IF, IHC, IP |
| Dilutions | Western Blot (1:500-1000); Flow Cytometry (1:100); Immunofluorescence (1:50-100); Immunohistochemistry (1:10-1:500); Immunoprecipitation (2 μg/500 µL) |
| MW(KDa) | 44 |
| Reactivity | Human, Canine |
| Specificity | This antibody is specific for Homo sapiens mitogen-activated protein kinase kinase 4 (MAP2K4). |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (pH 7.3), 1.0% BSA and 50% Glycerol. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.